Invitrogen

Phospho-PYK2 (Tyr579, Tyr580) Polyclonal Antibody

高级验证
10个已发表图片
11 篇参考文献
查看其他34个PYK2抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

44-636G

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:10-1:100
-

免疫细胞化学 (ICC/IF)

1:250
-

免疫沉淀 (IP)

-
查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosines 579 and 580. The sequence is conserved in mouse and rat.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533706

靶标信息

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CADTK; CAK beta; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; cellular adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; FRNK; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase

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基因别名: CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK

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UniProt ID: (Human) Q14289, (Rat) P70600, (Mouse) Q9QVP9

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Entrez Gene ID: (Human) 2185, (Rat) 50646, (Mouse) 19229

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功能
calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity NMDA glutamate receptor activity receptor binding protein binding ATP binding protein complex binding 3-phosphoinositide-dependent protein kinase binding protein kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
参与通路
MAPK cascade response to reactive oxygen species angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis marginal zone B cell differentiation protein phosphorylation cellular defense response response to osmotic stress actin filament organization cell adhesion cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion response to organonitrogen compound positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation peptidyl-tyrosine phosphorylation cell differentiation regulation of cell adhesion negative regulation of ossification positive regulation of cell growth positive regulation of cell migration negative regulation of bone mineralization regulation of cGMP biosynthetic process positive regulation of actin filament polymerization neuron projection development regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity negative regulation of apoptotic process stress fiber assembly negative regulation of potassium ion transport positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade vascular endothelial growth factor receptor signaling pathway focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of reactive oxygen species metabolic process positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis adaptive immune response protein complex assembly apoptotic process response to stress signal transduction positive regulation of nitric oxide biosynthetic process protein autophosphorylation long term synaptic depression positive regulation of DNA biosynthetic process immune system process cytoskeleton organization phosphorylation cell migration
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