Product References
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2.
Nature neuroscience
Dridi H,Liu Y,Reiken S,Liu X,Argyrousi EK,Yuan Q,Miotto MC,Sittenfeld L,Meddar A,Soni RK,Arancio O,Lacampagne A,Marks AR
44-734G was used in Western Blot to propose that HF is a systemic illness driven by intracellular Ca2+ leak that includes cardiogenic dementia.
Tue Aug 01 00:00:00 UTC 2023
Passive immunization against phosphorylated tau improves features of Huntington's disease pathology.
Molecular therapy : the journal of the American Society of Gene Therapy
Alpaugh M,Masnata M,de Rus Jacquet A,Lepinay E,Denis HL,Saint-Pierre M,Davies P,Planel E,Cicchetti F
44-734G was used in Western Blotting to suggest that attenuating tau pathology could mitigate behavioral and molecular hallmarks associated with Huntington's disease.
Wed Apr 06 00:00:00 UTC 2022
Passive immunization against phosphorylated tau improves features of Huntington's disease pathology.
Molecular therapy : the journal of the American Society of Gene Therapy
Alpaugh M,Masnata M,de Rus Jacquet A,Lepinay E,Denis HL,Saint-Pierre M,Davies P,Planel E,Cicchetti F
44-734G was used in Western Blotting to suggest that attenuating tau pathology could mitigate behavioral and molecular hallmarks associated with Huntington's disease.
Wed Apr 06 00:00:00 UTC 2022
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
International journal of molecular sciences
Lei L,Feng J,Wu G,Wei Z,Wang JZ,Zhang B,Liu R,Liu F,Wang X,Li HL
44-734G was used in Functional Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that chronic hypoxia upregulates HIF-1α, which obviously accelerated LCMT1 degradation, thus counteracting its transcriptional expression and suggest lowering HIF-1α in chronic hypoxia conditions may be useful in AD prevention.
Sat Dec 17 00:00:00 UTC 2022
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
International journal of molecular sciences
Lei L,Feng J,Wu G,Wei Z,Wang JZ,Zhang B,Liu R,Liu F,Wang X,Li HL
44-734G was used in Functional Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that chronic hypoxia upregulates HIF-1α, which obviously accelerated LCMT1 degradation, thus counteracting its transcriptional expression and suggest lowering HIF-1α in chronic hypoxia conditions may be useful in AD prevention.
Sat Dec 17 00:00:00 UTC 2022
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
International journal of molecular sciences
Lei L,Feng J,Wu G,Wei Z,Wang JZ,Zhang B,Liu R,Liu F,Wang X,Li HL
44-734G was used in Functional Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that chronic hypoxia upregulates HIF-1α, which obviously accelerated LCMT1 degradation, thus counteracting its transcriptional expression and suggest lowering HIF-1α in chronic hypoxia conditions may be useful in AD prevention.
Sat Dec 17 00:00:00 UTC 2022
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
International journal of molecular sciences
Song L,Oseid DE,Wells EA,Robinson AS
44-734G was used in Immunocytochemistry to investigate the effect of glycogen synthase kinase 3β (GSK3β) on tau pathology.
Sat Oct 01 00:00:00 UTC 2022
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
International journal of molecular sciences
Song L,Oseid DE,Wells EA,Robinson AS
44-734G was used in Immunocytochemistry to investigate the effect of glycogen synthase kinase 3β (GSK3β) on tau pathology.
Sat Oct 01 00:00:00 UTC 2022
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
International journal of molecular sciences
Song L,Oseid DE,Wells EA,Robinson AS
44-734G was used in Immunocytochemistry to investigate the effect of glycogen synthase kinase 3β (GSK3β) on tau pathology.
Sat Oct 01 00:00:00 UTC 2022
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
44-734G was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 UTC 2022
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
44-734G was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 UTC 2022
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Cell death and differentiation
Zhao D,Zhou Y,Huo Y,Meng J,Xiao X,Han L,Zhang X,Luo H,Can D,Sun H,Huang TY,Wang X,Zhang J,Liu FR,Xu H,Zhang YW
44-734G was used in Western Blot to observe retarded axon outgrowth, elevated p35 and p25 protein levels, and increased tau phosphorylation at major Cdk5 phosphorylation sites in Rps23rg1 knockout (KO) mice.
Fri Jan 01 00:00:00 UTC 2021
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Clinical and translational medicine
Wu D,Gao D,Yu H,Pi G,Xiong R,Lei H,Wang X,Liu E,Ye J,Yu H,Gao Y,He T,Jiang T,Sun F,Su J,Song G,Peng W,Yang Y,Wang JZ
44-734G was used in Western Blot to observe an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons.
Tue Jun 01 00:00:00 UTC 2021
Truncation of Tau selectively facilitates its pathological activities.
The Journal of biological chemistry
Gu J,Xu W,Jin N,Li L,Zhou Y,Chu D,Gong CX,Iqbal K,Liu F
44-734G was used in Western Blotting to suggest that the first 150 aa and the last 50 aa protect Tau from pathological characteristics and that their deletions facilitate pathological activities.
Fri Oct 02 00:00:00 UTC 2020
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder.
Nature communications
Egervari G,Akpoyibo D,Rahman T,Fullard JF,Callens JE,Landry JA,Ly A,Zhou X,Warren N,Hauberg ME,Hoffman G,Ellis R,Ferland JN,Miller ML,Keller E,Zhang B,Roussos P,Hurd YL
44-734G was used in Western Blotting to reveal distinct neuronal and non-neuronal epigenetic signatures, and identify a locus in the proximity of the gene encoding tyrosine kinase FYN as the most affected region in neurons.
Mon Sep 14 00:00:00 UTC 2020
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
Frontiers in aging neuroscience
Miao J,Shi R,Li L,Chen F,Zhou Y,Tung YC,Hu W,Gong CX,Iqbal K,Liu F
44-734G was used in Western Blotting to speculate that AD P-tau seeds hyperphosphorylated tau to form aggregates, which resist to the dephosphorylation by PP2A, resulting in hyperphosphorylation and pathology of tau.
Thu Oct 01 00:00:00 UTC 2020
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.
Scientific reports
Zhang Y,Wu F,Iqbal K,Gong CX,Hu W,Liu F
44-734G was used in Western Blotting to characterise Alzheimer-like alterations behaviourally, biochemically and immunohistochemically 6 weeks and 7 months after unilateral mild-to-moderate controlled cortical impact in human tau transgenic mice.
Thu Mar 07 00:00:00 UTC 2019
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.
Frontiers in aging neuroscience
Zhou Y,Shi J,Chu D,Hu W,Guan Z,Gong CX,Iqbal K,Liu F
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Western Blot
Sat Apr 09 00:00:00 UTC 2022
Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments.
Journal of Alzheimer's disease : JAD
Mahaman YAR,Huang F,Wu M,Wang Y,Wei Z,Bao J,Salissou MTM,Ke D,Wang Q,Liu R,Wang JZ,Zhang B,Chen D,Wang X
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Western Blot
Mon Jun 10 00:00:00 UTC 2019
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Journal of Alzheimer's disease : JAD
Hu W,Tung YC,Zhang Y,Liu F,Iqbal K
44-734G was used in Western Blotting to test the effect of repetitive mild traumatic brain injury on tau hyperphosphorylation, in triple-transgenic mouse model of Alzheimer's disease.
Mon Jul 15 00:00:00 UTC 2019
Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats.
Aging
Salissou MTM,Mahaman YAR,Zhu F,Huang F,Wang Y,Xu Z,Ke D,Wang Q,Liu R,Wang JZ,Zhang B,Wang X
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Western Blot
Mon Nov 12 00:00:00 UTC 2018
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Acta neuropathologica communications
Neddens J,Temmel M,Flunkert S,Kerschbaumer B,Hoeller C,Loeffler T,Niederkofler V,Daum G,Attems J,Hutter-Paier B
44-734G was used in Immunohistochemistry to investigate total tau and phosphorylated tau as well as amyloid-Β plaques in human brain tissue of Alzheimer's disease patients and controls.
Fri Jun 29 00:00:00 UTC 2018
Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis.
Frontiers in aging neuroscience
Hu W,Wu F,Zhang Y,Gong CX,Iqbal K,Liu F
44-734G was used in Dot blot to provide the regional expression profiles of tau and tau pathology-related proteins in the brain.
Thu Oct 01 00:00:00 UTC 2020
Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model.
Experimental and therapeutic medicine
Wang Y,Ma Q,Ma X,Zhang Z,Liu N,Wang M
44-734G was used in Western Blotting to investigate the role of mammalian target of rapamycin signalling in autophagy and the neurodegenerative process.
Tue Aug 01 00:00:00 UTC 2017
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.
Cell reports
Tseng JH,Xie L,Song S,Xie Y,Allen L,Ajit D,Hong JS,Chen X,Meeker RB,Cohen TJ
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Immunocytochemistry
Tue Aug 29 00:00:00 UTC 2017
Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.
The American journal of pathology
Winston CN,Noël A,Neustadtl A,Parsadanian M,Barton DJ,Chellappa D,Wilkins TE,Alikhani AD,Zapple DN,Villapol S,Planel E,Burns MP
44-734G was used in western blot to characterize chronic white matter inflammation and dendritic spine loss in a mouse model of highly repetitive head trauma
Tue Mar 01 00:00:00 UTC 2016
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Journal of Alzheimer's disease : JAD
Zimova I,Brezovakova V,Hromadka T,Weisova P,Cubinkova V,Valachova B,Filipcik P,Jadhav S,Smolek T,Novak M,Zilka N
44734G was used in western blot to describe the molecular and behavioral features of R3m/4 transgenic mice expressing human non-mutated truncated tau protein and assess these mice as a model for Alzheimer's disease
Tue Sep 06 00:00:00 UTC 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-734G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 UTC 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-734G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 UTC 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-734G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 UTC 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
44-734G was used in western blot to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 UTC 2016
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.
Experimental gerontology
Griñan-Ferré C,Palomera-Ávalos V,Puigoriol-Illamola D,Camins A,Porquet D,Plá V,Aguado F,Pallàs M
44-734G was used in Western Blotting to find impairment in emotional behaviour with regard to fear and anxiety in young SAMP8 vs. age-mated SAMR1.
Fri Jul 01 00:00:00 UTC 2016
Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.
Neurobiology of aging
Wang Y,Yang R,Gu J,Yin X,Jin N,Xie S,Wang Y,Chang H,Qian W,Shi J,Iqbal K,Gong CX,Cheng C,Liu F
44-734G was used in western blot to study the role of glycogen synthase kinase-3beta and protein phosphatase 2A in regulation of tau hyperphosphorylation
Thu Jan 01 00:00:00 UTC 2015
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
44-734G was used in western blot to research Alzheimer's disease brain and neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau
Tue Oct 13 00:00:00 UTC 2015
Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation.
Scientific reports
Wang Y,Zhang Y,Hu W,Xie S,Gong CX,Iqbal K,Liu F
44-734G was used in western blot to characterize postmortem behavior and the rapid alteration of protein phosphorylation
Thu Oct 29 00:00:00 UTC 2015
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.
Acta neuropathologica communications
Sottejeau Y,Bretteville A,Cantrelle FX,Malmanche N,Demiaute F,Mendes T,Delay C,Alves Dos Alves H,Flaig A,Davies P,Dourlen P,Dermaut B,Laporte J,Amouyel P,Lippens G,Chapuis J,Landrieu I,Lambert JC
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Western Blot
Wed Sep 23 00:00:00 UTC 2015
Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).
Age (Dordrecht, Netherlands)
Porquet D,Andrés-Benito P,Griñán-Ferré C,Camins A,Ferrer I,Canudas AM,Del Valle J,Pallàs M
44-734G was used in western blot to characterize cognitive and neuropathological Alzheimer's disease markers in a novel mouse model
Sun Feb 01 00:00:00 UTC 2015
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
The European journal of neuroscience
Maurin H,Lechat B,Borghgraef P,Devijver H,Jaworski T,Van Leuven F
44-734G was used in western blot to study the lack of involvementof GSK3-alpha/beta in the elevated tau phosphorylation observed in Tau.P30L hypothermic mice
Tue Jul 01 00:00:00 UTC 2014
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
PloS one
Petry FR,Pelletier J,Bretteville A,Morin F,Calon F,Hébert SS,Whittington RA,Planel E
44-734G was used in western blot to study the specificity of a panel of commonly used anti-tau antibodies and issues likely to be encounted in Western blot experiments using material from murine Alzheimer's disease models
Mon Dec 22 00:00:00 UTC 2014
Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Biochimica et biophysica acta
Pedrós I,Petrov D,Allgaier M,Sureda F,Barroso E,Beas-Zarate C,Auladell C,Pallàs M,Vázquez-Carrera M,Casadesús G,Folch J,Camins A
44-734G was used in western blot to investigate the abnormalites in hippocampal energy metabolism in the pathogenesis of Alzheimer disease.
Mon Sep 01 00:00:00 UTC 2014
Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.
PloS one
Oaks AW,Frankfurt M,Finkelstein DI,Sidhu A
44-734G was used in western blot to use a mouse model to examine motor activity, anxiety-like, and depressive-like behaviors both before and after the onset of Parkinson's disease
Mon Sep 16 00:00:00 UTC 2013
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
Molecular brain
Maurin H,Lechat B,Dewachter I,Ris L,Louis JV,Borghgraef P,Devijver H,Jaworski T,Van Leuven F
44-734G was used in western blot to investigate the contribution of GSK3α to neurological diseases.
Sat May 25 00:00:00 UTC 2013
An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.
Acta neuropathologica
Bolognin S,Blanchard J,Wang X,Basurto-Islas G,Tung YC,Kohlbrenner E,Grundke-Iqbal I,Iqbal K
44-734G was used in immunohistochemistry - free floating and western blot to report that expression of the N-terminal I2NTF and C-terminal I2CTF halves of I2PP2A in rat brain reproduced key features of Alzheimer's disease
Sun Jan 01 00:00:00 UTC 2012
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.
Autophagy
Congdon EE,Wu JW,Myeku N,Figueroa YH,Herman M,Marinec PS,Gestwicki JE,Dickey CA,Yu WH,Duff KE
44-734G was used in western blot to report that autophagy is a mechanism by which methylene blue reduces tau levels.
Sun Apr 01 00:00:00 UTC 2012
Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity.
Journal of neurochemistry
Park SS,Jung HJ,Kim YJ,Park TK,Kim C,Choi H,Mook-Jung IH,Koo EH,Park SA
44-734G was used in western blot to investigate the effect of caspase cleavage of APP on tau phosphorylation in relation to Aβ.
Sat Dec 01 00:00:00 UTC 2012
Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice.
Journal of neuropathology and experimental neurology
Tran HT,Sanchez L,Brody DL
Published figure using Phospho-Tau (Ser199) polyclonal antibody (Product # 44-734G) in Immunohistochemistry
Wed Feb 01 00:00:00 UTC 2012
The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang X,Blanchard J,Kohlbrenner E,Clement N,Linden RM,Radu A,Grundke-Iqbal I,Iqbal K
Mon Nov 01 00:00:00 UTC 2010
The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang X,Blanchard J,Kohlbrenner E,Clement N,Linden RM,Radu A,Grundke-Iqbal I,Iqbal K
Mon Nov 01 00:00:00 UTC 2010
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 UTC 2009
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 UTC 2009
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients.
Biogerontology
Wai MS,Liang Y,Shi C,Cho EY,Kung HF,Yew DT
44-734G was used in immunohistochemistry to compare the distribution and number of neurons with hyperphosphorylated tau in two age groups of Alzheimer's disease brainstems
Sat Aug 01 00:00:00 UTC 2009
Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.
The Journal of biological chemistry
Liu F,Iqbal K,Grundke-Iqbal I,Rossie S,Gong CX
Fri Jan 21 00:00:00 UTC 2005
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.jpg?time=20240412?time=20240412 "Phospho-Tau (Ser199) Antibody (44-734G) in WB")
