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Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171
基因别名: fa18f07; fb09f05; sr:nyz128; wu:fa18f07; wu:fb09f05
Entrez Gene ID: (Zebrafish) 321346