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Pur-alpha Antibody (A303-543A) in WB
Detection of human and mouse Pur-alpha by western blot (h and m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg), Jurkat (J; 50 µg) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-Pur-alpha antibody (Product # A303-543A) used for WB at 0.1 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. Pur-alpha was more efficiently immunoprecipitated by rabbit anti-Pur-alpha antibody A303-544A, which recognizes a downstrea... View More
产品信息
A303-543A
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1 and 50 of Human Purine-Rich Element Binding Protein Alpha.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pur alpha; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; Transcriptional activator protein Pur-alpha
基因别名: CAGER-1; MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA; ssCRE-BP
UniProt ID: (Human) Q00577, (Mouse) P42669
Entrez Gene ID: (Human) 5813, (Mouse) 19290
translation repressor activity, nucleic acid binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
purine-rich negative regulatory element binding
poly(A) RNA binding
SMAD binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
DNA unwinding involved in DNA replication
DNA replication initiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
negative regulation of translation
cell differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
mitotic cell cycle checkpoint
cell proliferation
