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产品信息
PA5-32174
产品规格
种属反应
Yeast
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 187 of Yeast RAD3
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2549647
产品详细信息
Recommended positive controls: Yeast lysate.
Predicted reactivity: Yeast (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ATP-dependent DNA helicase involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Necessary for excision of pyrimidine dimers. Also unwinds DNA/RNA duplexes. Plays an essential role in the cell viability. Involved in the maintenance of the fidelity of DNA replication. Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA 5'-3' helicase RAD3; DNA repair helicase RAD3; General transcription and DNA repair factor IIH helicase subunit XPD/RAD3; RNA polymerase II transcription factor B subunit RAD3; TFB subunit RAD3; TFIIH subunit XPD
基因别名: RAD3; REM1; YER171W
UniProt ID: (Baker's yeast) P06839
Entrez Gene ID: (Baker's yeast) 856918
nucleotide binding
nucleic acid binding
DNA binding
DNA helicase activity
damaged DNA binding
helicase activity
ATP binding
DNA-dependent ATPase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
5'-3' DNA helicase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
DNA helicase
regulation of mitotic recombination
nucleotide-excision repair, DNA duplex unwinding
nucleobase-containing compound metabolic process
DNA repair
nucleotide-excision repair
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
regulation of transposition, RNA-mediated
nucleotide-excision repair, DNA incision
positive regulation of mitotic recombination
phosphorylation of RNA polymerase II C-terminal domain
