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产品信息
H00003843-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RANBP5 (AAH45640.1, 1 a.a. approximately 1115 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPEDQVGKLE ATENTISAMA AAAAEQQQFY LLLGNLLSPD NVVRKQAEET YENIPGQSKI TFLLQAIRNT TAAEEARQMA AVLLRRLLSS AFDEVYPALP SDVQTAIKSE LLMIIQMETQ SSMRKKVCDI AAELARNLID EDGNNQWPEG LKFLFDSVSS QNVGLREAAL HIFWNFPGIF GNQQQHYLDV IKRMLVQCMQ DQEHPSIRTL SARATAAFIL ANEHNVALFK HFADLLPGFL QAVNDSCYQN DDSVLKSLVE IADTVPKYLR PHLEATLQLS LKLCGDTSLN NMQRQLALEV IVTLSETAAA MLRKHTNIVA QTIPQMLAMM VDLEEDEDWA NADELEDDDF DSNAVAGESA LDRMACGLGG KLVLPMIKEH IMQMLQNPDW KYRHAGLMAL SAIGEGCHQQ MEGILNEIVN FVLLFLQDPH PRVRYAACNA VGQMATDFAP GFQKKFHEKV IAALLQTMED QGNQRVQAHA AAALINFTED CPKSLLIPYL DNLVKHLHSI MVLKLQELIQ KGTKLVLEQV VTSIASVADT AEEKFVPYYD LFMPSRKHIV ENAVQKELRL LRGKTIECIS LIGLAVGKEK FMQDASDVMQ LLLKTQTDFN DMEDDDPQIS YMISAWARMC KILGKEFQQY LPVVMGPLMK TASIKPEVAL LDTQDMENMS DDDGWEFVNL GDQQSFGIKT AGLEEKSTAC QMLVCYAKEL KEGFVEYTEQ VVKLMVPLLK FYFHDGVRVA AAESMPLLLE CARVRGPEYL TQMWHFMCDA LIKAIGTEPD SDVLSEIMHS FAKCIEVMGD GCLNNEHFEE LGGILKAKLE EHFKNQELRQ VKRQDEDYDE QVEESLQDED DNDVYILTKV SDILHSIFSS YKEKVLPWFE QLLPLIVNLI CPHRPWPDRQ WGLCIFDDVI EHCSPASFKY AEYFLRPMLQ YVCDNSPEVR QAAAYGLGVM AQYGGDNYRP FCTEALPLLV RVIQSADSKT KENVNATENC ISAVGKIMKF KPDCVNVEEV LPHWLSWLPL HEDKEEAVQT FNYLCDLIES NHPIVLGPNN TNLPKIFSII AEGEMHEAIK HEDPCAKRLA NVVRQVQTSG GLWTECIAQL SPEQQAAIQE LLNSA
靶标信息
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Imp5; importin 5; importin beta-3 subunit; Importin subunit beta-3; Importin-5; IPO 5; karyopherin (importin) beta 3; Karyopherin beta 3; Karyopherin beta-3; MGC2068; RAN binding protein 5; Ran-binding protein 5; Ran_GTP binding protein 5; RanBP 5; RanBP5
基因别名: IMB3; imp5; IPO5; KPNB3; Pse1; RANBP5
UniProt ID: (Human) O00410
Entrez Gene ID: (Human) 3843, (Rat) 306182
protein import into nucleus, docking
protein import into nucleus, translocation
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
viral process
negative regulation of GTPase activity
positive regulation of protein import into nucleus
cellular response to amino acid stimulus
intracellular protein transport
