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RARB Antibody (PA5-81249) in ICC/IF
Immunofluorescence staining of RARB in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with RARB Polyclonal Antibody (Product # PA5-81249, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus.
产品信息
PA5-81249
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Mouse RARB/Retinoic Acid Receptor beta
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788474
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse RARB.
靶标信息
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta
基因别名: A830025K23; Hap; Nr1b2; Rarb
UniProt ID: (Mouse) P22605
Entrez Gene ID: (Mouse) 218772
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
drug binding
zinc ion binding
protein complex binding
sequence-specific DNA binding
metal ion binding
retinoid X receptor binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
glandular epithelial cell development
outflow tract septum morphogenesis
retinal pigment epithelium development
growth plate cartilage development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
striatum development
neurogenesis
regulation of myelination
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
steroid hormone mediated signaling pathway
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
embryonic digestive tract development
ventricular cardiac muscle cell differentiation
retina development in camera-type eye
bone development
negative regulation of cartilage development
