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RPSA Antibody (PA5-27281) in IHC (P)
RPSA Polyclonal Antibody detects RPSA protein at cytoplasm on mouse small intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse small intestine. RPSA Polyclonal Antibody (Product # PA5-27281) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-27281
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 294 of Human RPSA
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2544757
产品详细信息
Recommended positive controls: HepG2, Jurkat, Mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (93%), Xenopus laevis (95%), Dog (100%), Pig (100%), Chicken (98%), Sheep (99%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); Laminin-binding protein precursor p40; LamR; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; P40-3, functional; P40-8, functional; rssa; Small ribosomal subunit protein uS2
基因别名: 37LRP; 67kDa; 67LR; AL022858; ICAS; LAMBR; Lamr; LAMR1; Lamrl1; LBP; LBP/p40; LRP; LRP/LR; MLR; NEM/1CHD4; P40; P40-3; P40-8; RPSA; SA
UniProt ID: (Human) P08865, (Mouse) P14206
Entrez Gene ID: (Human) 3921, (Mouse) 16785
ribosomal small subunit assembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA processing
rRNA export from nucleus
translation
translational initiation
SRP-dependent cotranslational protein targeting to membrane
cell adhesion
viral transcription
viral entry into host cell
single organismal cell-cell adhesion
