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RSPO3 Antibody (PA5-100324) in ICC/IF
Immunofluorescent analysis of RSPO3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and RSPO3 polyclonal antibody (Product # PA5-100324) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100324
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RSPO3(Accession Q9BXY4), corresponding to amino acid residues F63-K113.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2849838
产品详细信息
Antibody detects endogenous levels of total RSPO3.
靶标信息
RSPO3 is a member of the R-spondin family and plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. RSPO3 has been shown to be involved in regulating the balance between angioblast and blood cell specification during embryonic vasculogenesis and angiogenesis and may be involved in tumor development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cabriolet; cristin 1; Cristin-1; Cysteine-rich and single thrombospondin domain-containing protein 1; hPWTSR; hRspo3; Nucleopondin; Protein with TSP type-1 repeat; R-spondin 3 homolog; R-spondin 3-like protein; R-spondin-3; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain 2; thrombospondin, type I, domain containing 2
基因别名: 2810459H04Rik; AW742308; CRISTIN1; PWTSR; RGD1563246; RSPO3; THSD2
UniProt ID: (Human) B2RC27, (Mouse) Q2TJ95
Entrez Gene ID: (Human) 84870, (Mouse) 72780, (Rat) 498997
angiogenesis
Wnt signaling pathway
response to stimulus
branching involved in labyrinthine layer morphogenesis
positive regulation of canonical Wnt signaling pathway
biological_process
canonical Wnt signaling pathway
blood vessel remodeling
sprouting angiogenesis
positive regulation of Wnt signaling pathway
positive regulation of non-canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway, planar cell polarity pathway
