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产品信息
OSR00377W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 750-800 of mouse Rubicon conjugated to an immunogenic carrier protein has been used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in human and rat.
Specificity of this antibody: Rubicon.
靶标信息
Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation. Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex. Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Baron; Beclin-1 associated RUN domain containing protein; Rubicon; RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; run domain Beclin-1 interacting and cystein-rich containing protein; run domain Beclin-1 interacting and cysteine-rich containing protein; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; RUN domain protein as Beclin 1-interacting and cysteine-rich containing; rundataxin; similar to mKIAA0226 protein
基因别名: 5330403K09; KIAA0226; mKIAA0226; RUBCN; RUBICON; SCAR15
UniProt ID: (Mouse) Q80U62, (Human) Q92622
Entrez Gene ID: (Mouse) 100502698, (Rat) 303885, (Human) 9711
biological_process
negative regulation of autophagy
negative regulation of endocytosis
immune system process
phagocytosis
negative regulation of phosphatidylinositol 3-kinase activity
multivesicular body sorting pathway
autophagosome maturation
negative regulation of autophagosome maturation
endocytosis
autophagy
