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SCN2A Antibody (PA5-87993) in WB
Western blot analysis of SCN2A in extracts of various cell lines. Samples were incubated with SCN2A Polyclonal antibody (Product # PA5-87993) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-87993
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 275-401 of human SCN2A (NP_0010352321)
偶联物
形式
Liquid
浓度
3 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804571
产品详细信息
Immunogen sequence: RNKCLQWPPD NSSFEINITS FFNNSLDGNG TTFNRTVSIF NWDEYIEDKS HFYFLEGQND ALLCGNSSDA GQCPEGYICV KAGRNPNYGY TSFDTFSWAF LSLFRLMTQD FWENLYQLTL RAAGKTY; Positive Samples: U-87MG, K-562; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain Type II; HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.2; voltage-gated sodium channel type II alpha subunit
基因别名: BFIC3; BFIS3; BFNIS; EIEE11; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; Nav1.2; SCN2A; SCN2A1; SCN2A2
UniProt ID: (Human) Q99250
Entrez Gene ID: (Human) 6326
sodium ion transport
intrinsic apoptotic signaling pathway in response to osmotic stress
neuronal action potential
regulation of ion transmembrane transport
sodium ion transmembrane transport
myelination
neuron apoptotic process
regulation of postsynaptic membrane potential
membrane depolarization during action potential
