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SCN4B (NaV beta 4) (extracellular) Antibody (ASC-044-200UL) in ICC/IF
Expression of NaV beta 4 in rat PC12 cells - Cell surface detection of NaV beta 4 in intact living ratpheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-SCN4B (NaV beta 4) (extracellular) Antibody (#ASC-044), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells.
产品信息
ASC-044-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85-98 of rat beta 4 subunit of voltage-gated Na+channels, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sodium channel accessory subunit; sodium channel beta 4 subunit; Sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; sodium channel, voltage gated, type IV beta subunit; sodium channel, voltage-gated, type IV, beta subunit; voltage gated sodium channel beta 4 subunit
基因别名: ATFB17; Gm1471; LQT10; Navbeta4; SCN4B
UniProt ID: (Human) Q8IWT1, (Rat) Q7M730, (Mouse) Q7M729
Entrez Gene ID: (Human) 6330, (Rat) 315611, (Mouse) 399548
sodium ion transport
positive regulation of sodium ion transport
sodium ion transmembrane transport
cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
AV node cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
biological_process
regulation of ion transmembrane transport
AV node cell to bundle of His cell communication
transport
ion transport
