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产品信息
PA5-143761
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Semaphorin 6A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the cytoplasmic region of human Sema-6A. The sequence used has high homology to similar regions in rat and mouse Sema-6A, and has low homology to other semaphorin family members.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2942989
产品详细信息
The antibody detects a 120kDa* protein corresponding to the apparent molecular mass of Sema-6A on SDS-PAGE immunoblots of Sema-6A transfected COS7 cells, human colorectal cancer cells, and rat PC12 cells. In addition, shRNA knockdown of Sema-6A expression significantly reduces detection of Sema-6A using anti-Sema-6A (a.a. 772-787) antibody.
靶标信息
SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mutant line 997; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; Sema Q; Sema VIA; SEMA6A-1; semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; Semaphorin-6A; Semaphorin-6A-1
基因别名: 9330158E07; A730020P05Rik; AI851735; b2b997Clo; HT018; KIAA1368; SEMA; SEMA6A; Sema6A-1; SEMA6A1; SEMAQ; VIA
UniProt ID: (Human) Q9H2E6, (Mouse) O35464
Entrez Gene ID: (Human) 57556, (Rat) 361324, (Mouse) 20358
neural crest cell migration
apoptotic process
cytoskeleton organization
cell surface receptor signaling pathway
nervous system development
axon guidance
organ morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
semaphorin-plexin signaling pathway
positive regulation of neuron migration
neuron migration
multicellular organism development
centrosome localization
cell differentiation
