SIRT1 Monoclonal Antibody (1F3)

core promoter sequence-specific DNA binding p53 binding transcription corepressor activity NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding protein C-terminus binding transcription factor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein deacetylase activity NAD-dependent protein deacetylase activity nuclear hormone receptor binding histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) mitogen-activated protein kinase binding NAD+ binding keratin filament binding

single strand break repair negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA pyrimidine dimer repair by nucleotide-excision repair DNA synthesis involved in DNA repair angiogenesis ovulation from ovarian follicle cellular glucose homeostasis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation positive regulation of adaptive immune response DNA replication DNA repair chromatin organization chromatin silencing establishment of chromatin silencing maintenance of chromatin silencing methylation-dependent chromatin silencing transcription, DNA-templated rRNA processing protein ADP-ribosylation protein deacetylation triglyceride mobilization cellular response to DNA damage stimulus response to oxidative stress spermatogenesis regulation of mitotic cell cycle muscle organ development cell aging positive regulation of cell proliferation cellular response to starvation negative regulation of gene expression positive regulation of cholesterol efflux regulation of lipid storage regulation of glucose metabolic process macrophage cytokine production positive regulation of phosphatidylinositol 3-kinase signaling viral process positive regulation of macroautophagy protein ubiquitination histone deacetylation peptidyl-lysine acetylation macrophage differentiation negative regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of prostaglandin biosynthetic process protein destabilization positive regulation of chromatin silencing negative regulation of TOR signaling regulation of endodeoxyribonuclease activity negative regulation of NF-kappaB transcription factor activity response to insulin circadian regulation of gene expression regulation of protein import into nucleus, translocation leptin-mediated signaling pathway regulation of smooth muscle cell apoptotic process peptidyl-lysine deacetylation cellular triglyceride homeostasis regulation of peroxisome proliferator activated receptor signaling pathway regulation of cell proliferation negative regulation of phosphorylation response to hydrogen peroxide behavioral response to starvation cholesterol homeostasis intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of DNA damage response, signal transduction by p53 class mediator response to leptin positive regulation of MHC class II biosynthetic process negative regulation of fat cell differentiation positive regulation of DNA repair positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of insulin receptor signaling pathway white fat cell differentiation negative regulation of helicase activity positive regulation of histone H3-K9 methylation negative regulation of protein kinase B signaling fatty acid homeostasis negative regulation of androgen receptor signaling pathway histone H3-K9 modification cellular response to hydrogen peroxide regulation of bile acid biosynthetic process UV-damage excision repair histone H3 deacetylation cellular response to tumor necrosis factor negative regulation of histone H3-K14 acetylation cellular response to hypoxia cellular response to ionizing radiation regulation of protein serine/threonine kinase activity regulation of brown fat cell differentiation stress-induced premature senescence regulation of cellular response to heat negative regulation of neuron death negative regulation of protein acetylation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of adipose tissue development histone H3-K9 deacetylation positive regulation of macrophage apoptotic process negative regulation of cAMP-dependent protein kinase activity positive regulation of cAMP-dependent protein kinase activity negative regulation of histone H4-K16 acetylation negative regulation of cellular response to testosterone stimulus negative regulation of peptidyl-lysine acetylation negative regulation of cellular senescence positive regulation of cellular senescence