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产品信息
PA5-96816
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 149-448 of human INPP5K (NP_0576162)
偶联物
形式
Liquid
浓度
1.51 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808618
产品详细信息
Immunogen sequence: HLPPHISNNY QRLEHFDRIL EMQNCEGRDI PNILDHDLII WFGDMNFRIE DFGLHFVRES IKNRCYGGLW EKDQLSIAKK HDPLLREFQE GRLLFPPTYK FDRNSNDYDT SEKKRKPAWT DRILWRLKRQ PCAGPDTPIP PASHFSLSLR GYSSHMTYGI SDHKPVSGTF DLELKPLVSA PLIVLMPEDL WTVENDMMVS YSSTSDFPSS PWDWIGLYKV GLRDVNDYVS YAWVGDSKVS CSDNLNQVYI DISNIPTTED EFLLCYYSNS LRSVVGISRP FQIPPGSLRE DPLGEAQPQI; Positive Samples: Mouse brain, Rat brain; Cellular Location: Endoplasmic reticulum
靶标信息
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C62; Inositol polyphosphate 5-phosphatase K; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PI-5-phosphatase related; putative phosphoinositide 5-phosphatase type II; putative phosphoinositide 5-phosphatase type II; C62; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase
基因别名: C62; INPP5K; PPS; SKIP
UniProt ID: (Human) Q9BT40, (Mouse) Q8C5L6
Entrez Gene ID: (Human) 51763, (Rat) 287533, (Mouse) 19062
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
vasopressin receptor activity
protein binding
inositol bisphosphate phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol trisphosphate phosphatase activity
phosphatidylinositol phosphate 5-phosphatase activity
lipid phosphatase activity
inositol trisphosphate phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
molecular_function
hydrolase activity
phosphatase
in utero embryonic development
negative regulation of protein phosphorylation
regulation of glycogen biosynthetic process
negative regulation of protein kinase activity
phosphatidylinositol biosynthetic process
G-protein coupled receptor signaling pathway
negative regulation of peptidyl-threonine phosphorylation
negative regulation of glucose transport
dephosphorylation
actin cytoskeleton organization
cellular response to insulin stimulus
cellular response to hormone stimulus
negative regulation of peptidyl-serine phosphorylation
negative regulation of dephosphorylation
positive regulation of urine volume
glucose homeostasis
negative regulation of MAP kinase activity
negative regulation by host of viral transcription
negative regulation of glycogen biosynthetic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
negative regulation of stress fiber assembly
negative regulation of protein kinase B signaling
negative regulation of calcium ion transport
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein targeting to plasma membrane
negative regulation of protein targeting to membrane
ruffle assembly
negative regulation of glycogen (starch) synthase activity
positive regulation of renal water transport
biological_process
response to insulin
