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SLA2 Antibody (PA5-88777) in WB
Western blot analysis of SLA2 in extracts of various cell lines. Samples were incubated with SLA2 Polyclonal antibody (Product # PA5-88777) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-88777
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_1155901)
偶联物
形式
Liquid
浓度
3.01 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805124
产品详细信息
Immunogen sequence: MGSLPSRRKS LPSPSLSSSV QGQGPVTMEA ERSKATAVAL GSFPAGGPAE LSLRLGEPLT IVSEDGDWWT VLSEVSGREY NIPSVHVAKV SHGWLYEGLS REKAEELLLL PGNPGGAFLI RESQTRRGSY SLSVRLSRPA SWDRIRHYRI HCLDNGWLYI; Positive Samples: K-562, A-431, HT-29; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic vesicle
靶标信息
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MARS; Modulator of antigen receptor signaling; SLAP-2; Src-like adapter protein 2; Src-like adapter protein-2; Src-like-adapter 2; Src-like-adaptor 2
基因别名: C20orf156; MARS; SLA2; SLAP-2; SLAP2
UniProt ID: (Human) Q9H6Q3
Entrez Gene ID: (Human) 84174
negative regulation of transcription from RNA polymerase II promoter
positive regulation of signal transduction
B cell mediated immunity
intracellular receptor signaling pathway
T cell activation
regulation of immune response
negative regulation of calcium-mediated signaling
antigen receptor-mediated signaling pathway
negative regulation of B cell activation
