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产品信息
MA5-37985
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2287
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRD5A2 (P31213)
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897903
产品详细信息
Positive Samples: PC-3, Mouse liver, Mouse testis, Mouse kidney, Rat testis, Rat kidney
Immunogen sequence: MQVQCQQSPV LAGSATLVAL GALALYVAKP SGYGKHTESL KPAATRLPAR AAWFLQELPS FAVPAGILAR QPLSLFGPPG TVLLGLFCVH YFHRTFVYSL
靶标信息
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; MGC138457; S5AR 2; SR type 2; steroid 5 alpha reductase type2; Steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); Type II 5-alpha reductase
基因别名: 5ART2; S5AR 2; SRD5A2
UniProt ID: (Human) P31213, (Rat) P31214, (Mouse) Q99N99
Entrez Gene ID: (Human) 6716, (Rat) 64677, (Mouse) 94224
steroid biosynthetic process
androgen biosynthetic process
steroid catabolic process
cell-cell signaling
androgen metabolic process
male gonad development
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phthalate metabolic process
hippocampus development
hypothalamus development
cell differentiation
male genitalia development
female genitalia development
response to nutrient levels
response to follicle-stimulating hormone
response to testosterone
response to drug
response to peptide hormone
response to steroid hormone
oxidation-reduction process
bone development
sex differentiation
response to organic substance
response to organic cyclic compound
lipid metabolic process
steroid metabolic process
