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产品信息
PA5-62972
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647836
产品详细信息
Immunogen sequence: AWEERFSSLR RLTTIEKIKA EQSKQPPTPL LGRKFFGDPT ELAAKAAPLL RPGGYERGLE PLARRASDTL SAEVRTRVGY VRQELKPERL QPRIDRLP
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart. Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Beta-IV spectrin; EMBL BAB83243.1; spectrin beta chain, brain 3; Spectrin beta chain, non-erythrocytic 4; spectrin, beta, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3
基因别名: KIAA1642; QV; SPNB4; SPTBN3; SPTBN4
UniProt ID: (Human) Q9H254
Entrez Gene ID: (Human) 57731
MAPK cascade
regulation of sodium ion transport
ER to Golgi vesicle-mediated transport
cytoskeletal anchoring at plasma membrane
axonogenesis
axon guidance
sensory perception of sound
adult walking behavior
fertilization
negative regulation of heart rate
vesicle-mediated transport
transmission of nerve impulse
central nervous system projection neuron axonogenesis
regulation of peptidyl-serine phosphorylation
positive regulation of multicellular organism growth
positive regulation of GTPase activity
clustering of voltage-gated sodium channels
actin filament capping
cardiac conduction
establishment of protein localization to plasma membrane
