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MA5-15623 targets SYP in indirect ELISA, IHC and WB applications and shows reactivity with Human and Rat samples.
The MA5-15623 immunogen is purified recombinant fragment of SYP expressed in E. Coli.
MA5-15623 detects SYP which has a predicted molecular weight of approximately 33.8kDa.
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I
基因别名: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1
UniProt ID: (Human) P08247, (Rat) P07825, (Mouse) Q62277
Entrez Gene ID: (Human) 6855, (Rat) 24804, (Mouse) 20977