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Immunogen sequence: LWKDVTEAEQ AEEQARQEEQ VVRQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE ATMLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLL
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
WNK is a serine/threonine kinase that plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: transducin (beta)-like 3; Transducin beta-like protein 3; WD repeat-containing protein SAZD; WD-repeat protein SAZD
基因别名: SAZD; TBL3; UTP13
UniProt ID: (Human) Q12788
Entrez Gene ID: (Human) 10607