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TBX5 Antibody (PA5-29845) in IHC (P)
TBX5 Polyclonal Antibody detects TBX5 protein at nucleus on rat thyroid gland by immunohistochemical analysis. Sample: Paraffin-embedded rat thyroid gland. TBX5 Polyclonal Antibody (Product # PA5-29845) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-29845
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 243 of Human TBX5
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547319
产品详细信息
Recommended positive controls: HeLa nuclear extract, rat brain.
Predicted reactivity: Mouse (100%), Rat (99%), Japanese Medaka (94%), Xenopus laevis (98%), Chicken (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: T-box protein 5; T-box transcription factor TBX5
基因别名: HOS; TBX5
UniProt ID: (Human) Q99593, (Rat) Q5I2P1
Entrez Gene ID: (Human) 6910, (Rat) 304514
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
Rel homology transcription factor
morphogenesis of an epithelium
bundle of His development
atrioventricular valve morphogenesis
endocardial cushion development
cardiac left ventricle formation
ventricular septum development
transcription initiation from RNA polymerase II promoter
cell-cell signaling
pattern specification process
heart development
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
lung development
embryonic limb morphogenesis
negative regulation of cell migration
embryonic forelimb morphogenesis
forelimb morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
pericardium development
negative regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
transdifferentiation
atrial septum morphogenesis
cell migration involved in coronary vasculogenesis
positive regulation of secondary heart field cardioblast proliferation
regulation of execution phase of apoptosis
ventricular cardiac muscle tissue development
atrial septum development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic nuclear changes
