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产品信息
PA5-29225
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 172 and 438 of Human TID1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546701
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (80%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TID1 is a human homolog of the Drosophila tumor suppressor lethal (2) tumorous imaginal discs, l(2)tid and encodes two mitochondrial matrix localized splice variants of human Tid-1 designated hTid-1S and hTid-1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperones for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid-1L increases apoptosis induced by DNA damaging agents as mitomycin-C and TNF-a. A J-domain mutant of hTid-1L can dominantly suppress apoptosis and in sharp contrast the J-domain mutant of hTid-1S increases apoptosis. Expression of hTid-1S and hTid-1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti- and pro- apoptotic effects through discrete substrates and activities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; Hepatocellular carcinoma-associated antigen 57; hTid-1; Tumorous imaginal discs protein Tid56 homolog
基因别名: DNAJA3; HCA57; hTID-1; Tid-1; TID1
UniProt ID: (Human) Q96EY1
Entrez Gene ID: (Human) 9093, (Rat) 360481
negative regulation of transcription from RNA polymerase II promoter
mitochondrial DNA replication
protein folding
activation-induced cell death of T cells
mitochondrion organization
small GTPase mediated signal transduction
cell aging
negative regulation of cell proliferation
response to heat
T cell differentiation in thymus
positive regulation of T cell proliferation
negative regulation of programmed cell death
regulation of catalytic activity
skeletal muscle acetylcholine-gated channel clustering
negative regulation of protein kinase activity
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
neuromuscular junction development
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
response to interferon-gamma
protein refolding
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein stabilization
negative regulation of interferon-gamma-mediated signaling pathway
