Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
TYRO3 Antibody (PA5-110535) in WB
Western blot analysis of TYRO3 in extracts of various cell lines. Samples were incubated with TYRO3 Polyclonal antibody (Product # PA5-110535) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-110535
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human TYRO3 (NP_006284.2).
偶联物
形式
Liquid
浓度
0.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855946
产品详细信息
Immunogen sequence: PATNYSLRVR CANALGPSPY ADWVPFQTKG LAPASAPQNL HAIRTDSGLI LEWEEVIPEA PLEGPLGPYK LSWVQDNGTQ DELTVEGTRA NLTGWDPQKD LIVRVCVSNA VGCGPWSQPL VVSSHDRAGQ QGPPHSRTSW V
靶标信息
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Bruton agammaglobulinemia tyrosine kinase; Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
基因别名: AI323366; Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; TK19-2; Tyro3
UniProt ID: (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Mouse) 22174, (Rat) 25232
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
transmembrane signal receptor
natural killer cell differentiation
protein phosphorylation
cell adhesion
spermatogenesis
phosphorylation
peptidyl-tyrosine phosphorylation
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
protein autophosphorylation
negative regulation of inflammatory response
negative regulation of lymphocyte activation
vagina development
neuron cellular homeostasis
platelet aggregation
