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USP49 Antibody (PA5-104202) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded USP49 in human spleen tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with USP49 polyclonal antibody (Product # PA5-104202) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-104202
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human USP49(Accession Q70CQ1), corresponding to amino acid residues K295-I345.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853530
产品详细信息
Antibody detects endogenous levels of total USP49.
靶标信息
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 49; Ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; Ubiquitin thioesterase 49; ubiquitin thiolesterase 49; Ubiquitin-specific-processing protease 49
基因别名: C330046L10Rik; Gm545; RGD1310513; USP49
UniProt ID: (Human) Q70CQ1, (Mouse) Q6P9L4
Entrez Gene ID: (Human) 25862, (Mouse) 224836, (Rat) 316211
mRNA splicing, via spliceosome
ubiquitin-dependent protein catabolic process
protein deubiquitination
histone H2B conserved C-terminal lysine deubiquitination
mRNA processing
proteolysis
RNA splicing
chromatin modification
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
