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产品信息
PA5-16487
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat,
Rhesus monkey
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from C-terminus of the precursor form of the mouse Flk-1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
RRID
AB_10978670
产品详细信息
PA5-16487 targets Flk-1 in IHC (P) and WB applications and shows reactivity with mouse, Rat, and Human samples.
The PA5-16487 immunogen is a synthetic peptide from C-terminus of the precursor form of the mouse Flk-1.
靶标信息
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2
基因别名: 6130401C07; CD309; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2
UniProt ID: (Human) P35968, (Rat) O08775, (Mouse) P35918
Entrez Gene ID: (Human) 3791, (Rat) 25589, (Mouse) 16542
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
Hsp90 protein binding
vascular endothelial growth factor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
angiogenesis
ovarian follicle development
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
lymph vessel development
cell migration involved in sprouting angiogenesis
positive regulation of mesenchymal cell proliferation
endocardium development
endothelium development
endochondral bone growth
positive regulation of cytosolic calcium ion concentration
aging
positive regulation of cell proliferation
regulation of cell shape
male gonad development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
hyaluronan metabolic process
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of TOR signaling
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
peptidyl-tyrosine autophosphorylation
vascular endothelial growth factor signaling pathway
response to drug
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
cell fate commitment
endothelial cell differentiation
regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of vasodilation
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of long-term neuronal synaptic plasticity
lung alveolus development
cell maturation
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of neurogenesis
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
calcium ion homeostasis
positive regulation of ERK1 and ERK2 cascade
response to oxygen levels
regulation of hematopoietic progenitor cell differentiation
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
viral process
positive regulation of macroautophagy
signal transduction by protein phosphorylation
extracellular matrix organization
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
regulation of endothelial cell proliferation
protein phosphorylation
multicellular organism development
phosphorylation
cell differentiation
positive regulation of vascular endothelial growth factor receptor signaling pathway
blood vessel endothelial cell differentiation
