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XPA Antibody (MA1-21460) in WB, IHC
Cell transplantation 2022 -
Figure 5. XPA silencing increases temozolomide sensitivity in vivo . (A) U87 and U87-R cells stably transfected with shCon or shXPA, and subsequently injected into nude mice. Tumors were excised and volume was calculated every week. Representative images of isolated tumors were displayed. (B) The tumor inhibition rates according to the weight of explanted tumors in each experimental group. *** P... View More
产品信息
MA1-21460
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5A2
抗原
Recombinant human XPA (Xeroderma Pigmentosum group A) protein
偶联物
形式
Liquid
浓度
1.1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_561966
产品详细信息
Positive controls of LS174T, MCF-7 cells or human tonsil suggested. Works on pure and partially purified protein but not on crude cell extract.
靶标信息
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A
基因别名: XP1; XPA; XPAC
UniProt ID: (Human) P23025
Entrez Gene ID: (Human) 7507
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
response to oxidative stress
intrinsic apoptotic signaling pathway in response to DNA damage
response to toxic substance
response to auditory stimulus
nucleotide-excision repair, DNA incision
multicellular organism growth
global genome nucleotide-excision repair
UV-damage excision repair
nucleotide-excision repair involved in interstrand cross-link repair
