Product References
Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina.
The Journal of pathology
Owen N,Toms M,Tian Y,Toualbi L,Richardson R,Young R,Tracey-White D,Dhami P,Beck S,Moosajee M
PA1-46189 was used in Immunohistochemistry to identify six key modules involving cell cycle control and disturbance of TGFβ, bone morphogenetic protein (BMP), Hippo, and SMAD protein signal transduction pathways, revealing significant interactome hotspots relevant to crb2a function and confirming the epigenetic control of gene regulation in early retinal development, which points to a novel mechanism underlying CRB1-retinopathies.
Sat Apr 01 00:00:00 UTC 2023
Radiation therapy affects YAP expression and intracellular localization by modulating lamin A/C levels in breast cancer.
Frontiers in bioengineering and biotechnology
La Verde G,Artiola V,Pugliese M,La Commara M,Arrichiello C,Muto P,Netti PA,Fusco S,Panzetta V
PA1-46189 was used in Immunocytochemistry-immunofluorescence to elucidate the role of extracellular matrix stiffness and ionizing radiations on YAP regulation; and explored the behaviour of two different mammary cell lines, a normal epithelial cell line (MCF10A) and a highly aggressive and invasive adenocarcinoma cell line (MDA-MB-231) interacting with polyacrylamide substrates mimicking the mechanics of both normal and tumour tissues (∼1 and ∼13 kPa)..
Tue Sep 13 00:00:00 UTC 2022
Radiation therapy affects YAP expression and intracellular localization by modulating lamin A/C levels in breast cancer.
Frontiers in bioengineering and biotechnology
La Verde G,Artiola V,Pugliese M,La Commara M,Arrichiello C,Muto P,Netti PA,Fusco S,Panzetta V
PA1-46189 was used in Immunocytochemistry-immunofluorescence to elucidate the role of extracellular matrix stiffness and ionizing radiations on YAP regulation; and explored the behaviour of two different mammary cell lines, a normal epithelial cell line (MCF10A) and a highly aggressive and invasive adenocarcinoma cell line (MDA-MB-231) interacting with polyacrylamide substrates mimicking the mechanics of both normal and tumour tissues (∼1 and ∼13 kPa)..
Tue Sep 13 00:00:00 UTC 2022
Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation.
PloS one
Geiger F,Schnitzler LG,Brugger MS,Westerhausen C,Engelke H
PA1-46189 was used in Immunocytochemistry to study the influence of fiber orientation in the extracellular collagen matrix on invasion from a cancer cell spheroid.
Tue Apr 26 00:00:00 UTC 2022
Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation.
PloS one
Geiger F,Schnitzler LG,Brugger MS,Westerhausen C,Engelke H
PA1-46189 was used in Immunocytochemistry to study the influence of fiber orientation in the extracellular collagen matrix on invasion from a cancer cell spheroid.
Tue Apr 26 00:00:00 UTC 2022
Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing.
Pharmaceutics
Wu M,Matar DY,Yu Z,Chen Z,Knoedler S,Ng B,Darwish OA,Sohrabi S,Friedman L,Haug V,Murphy GF,Rinkevich Y,Orgill DP,Panayi AC
Published figure using YAP1 polyclonal antibody (Product # PA1-46189) in Immunohistochemistry
Thu Oct 06 00:00:00 UTC 2022
Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing.
Pharmaceutics
Wu M,Matar DY,Yu Z,Chen Z,Knoedler S,Ng B,Darwish OA,Sohrabi S,Friedman L,Haug V,Murphy GF,Rinkevich Y,Orgill DP,Panayi AC
Published figure using YAP1 polyclonal antibody (Product # PA1-46189) in Immunohistochemistry
Thu Oct 06 00:00:00 UTC 2022
Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses.
Journal of the Royal Society, Interface
Maremonti MI,Panzetta V,Dannhauser D,Netti PA,Causa F
PA1-46189 was used in ChIP assay to define specific nuclear signatures for cell mechanical phenotyping.
Fri Apr 01 00:00:00 UTC 2022
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation.
Cell death and differentiation
Canu V,Donzelli S,Sacconi A,Lo Sardo F,Pulito C,Bossel N,Di Benedetto A,Muti P,Botti C,Domany E,Bicciato S,Strano S,Yarden Y,Blandino G
PA1-46189 was used in Western Blotting to uncover an oncogenic feedback loop, comprising miR-10b-3p, SPAG5, and YAP/TAZ/TEAD, which fuels the aberrant proliferation of breast cancer.
Sat May 01 00:00:00 UTC 2021
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation.
Cell death and differentiation
Canu V,Donzelli S,Sacconi A,Lo Sardo F,Pulito C,Bossel N,Di Benedetto A,Muti P,Botti C,Domany E,Bicciato S,Strano S,Yarden Y,Blandino G
PA1-46189 was used in Western Blotting to uncover an oncogenic feedback loop, comprising miR-10b-3p, SPAG5, and YAP/TAZ/TEAD, which fuels the aberrant proliferation of breast cancer.
Sat May 01 00:00:00 UTC 2021
PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ganci F,Pulito C,Valsoni S,Sacconi A,Turco C,Vahabi M,Manciocco V,Mazza EMC,Meens J,Karamboulas C,Nichols AC,Covello R,Pellini R,Spriano G,Sanguineti G,Muti P,Bicciato S,Ailles L,Strano S,Fontemaggi G,Blandino G
PA1-46189 was used in ChIP assay to investigate mutant p53-associated functions through gene set enrichment analysis in the Cancer Genome Atlas cohort of head and neck squamous cell carcinoma and in a panel of 22 head and neck squamous cell carcinoma cell lines.
Mon Jun 15 00:00:00 UTC 2020
PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ganci F,Pulito C,Valsoni S,Sacconi A,Turco C,Vahabi M,Manciocco V,Mazza EMC,Meens J,Karamboulas C,Nichols AC,Covello R,Pellini R,Spriano G,Sanguineti G,Muti P,Bicciato S,Ailles L,Strano S,Fontemaggi G,Blandino G
PA1-46189 was used in ChIP assay to investigate mutant p53-associated functions through gene set enrichment analysis in the Cancer Genome Atlas cohort of head and neck squamous cell carcinoma and in a panel of 22 head and neck squamous cell carcinoma cell lines.
Mon Jun 15 00:00:00 UTC 2020
Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis.
The Journal of international medical research
Li H,Kan B,Song L,Liu Y,Jian X
PA1-46189 was used in Western Blotting to elucidate the molecular mechanisms by which safflower yellow (SY) mediates therapeutic effects in rats with paraquat intoxication-induced pulmonary fibrosis.
Tue Sep 01 00:00:00 UTC 2020
Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis.
The Journal of international medical research
Li H,Kan B,Song L,Liu Y,Jian X
PA1-46189 was used in Western Blotting to elucidate the molecular mechanisms by which safflower yellow (SY) mediates therapeutic effects in rats with paraquat intoxication-induced pulmonary fibrosis.
Tue Sep 01 00:00:00 UTC 2020
Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.
Cell death & disease
Han Y,Zhang L,Yu X,Wang S,Xu C,Yin H,Wang S
Published figure using YAP1 polyclonal antibody (Product # PA1-46189) in Immunohistochemistry
Fri May 10 00:00:00 UTC 2019
NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors.
Genes & cancer
McGowan M,Kleinberg L,Halvorsen AR,Helland Å,Brustugun OT
Published figure using YAP1 polyclonal antibody (Product # PA1-46189) in Immunofluorescence
Wed Mar 01 00:00:00 UTC 2017
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma.
Lung cancer (Amsterdam, Netherlands)
McGowan M,Hoven AS,Lund-Iversen M,Solberg S,Helland Å,Hirsch FR,Brustugun OT
PA1-46189 was used in ChIP Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that PIK3CA mutations may confer a survival advantage in early stage squamous cell lung cancers.
Sun Jan 01 00:00:00 UTC 2017
The clinical significance of forkhead box protein A1 and its role in colorectal cancer.
Molecular medicine reports
Ma W,Jiang J,Li M,Wang H,Zhang H,He X,Huang L,Zhou Q
PA1-46189 was used in western blot examine the impact of FOXA1 to colorectal cancer
Thu Sep 01 00:00:00 UTC 2016
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
Molecular cancer
Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
Sat May 17 00:00:00 UTC 2014
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
Molecular cancer
Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
Sat May 17 00:00:00 UTC 2014
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
Molecular cancer
Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
Sat May 17 00:00:00 UTC 2014
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
Molecular cancer
Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
Sat May 17 00:00:00 UTC 2014
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
Molecular cancer
Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
Sat May 17 00:00:00 UTC 2014