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ZIP3 (SLC39A3) Antibody (AZT-003-200UL) in IHC (F)
Expression of Zinc transporter ZIP3 in rat hippocampus - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-ZIP3 (SLC39A3) Antibody (#AZT-003), (1:400), followed by goat- Anti-rabbit-AlexaFluor-488 Antibody . ZIP3 staining (green) appears in CA1 neurons in the pyramidal layer (arrow). Nuclei are labeled with DAPI (blue).
产品信息
AZT-003-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EADFEKAHRSKK, corresponding to amino acid residues 31-42 of rat ZIP3, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: solute carrier family 39 (zinc transporter), member 3; Solute carrier family 39 member 3; Zinc transporter ZIP3; ZIP-3; Zrt- and Irt-like protein 3
基因别名: AI845814; SLC39A3; ZIP-3; ZIP3
UniProt ID: (Human) Q9BRY0, (Mouse) Q99K24, (Rat) Q5U1X7
Entrez Gene ID: (Human) 29985, (Mouse) 106947, (Rat) 314637
