p53 Monoclonal Antibody (PAb 122)

RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding copper ion binding protein binding ATP binding transcription factor binding zinc ion binding enzyme binding protein kinase binding protein phosphatase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding protein self-association transcription regulatory region DNA binding protein heterodimerization activity protein N-terminus binding chaperone binding protein phosphatase 2A binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription cofactor binding protein C-terminus binding histone deacetylase regulator activity MDM2/MDM4 family protein binding metal ion binding

protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter DNA strand renaturation in utero embryonic development somitogenesis release of cytochrome c from mitochondria T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment positive regulation of leukocyte migration response to ischemia nucleotide-excision repair double-strand break repair transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein complex assembly apoptotic process cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator response to oxidative stress ER overload response cell cycle cell cycle arrest transforming growth factor beta receptor signaling pathway multicellular organism development gastrulation negative regulation of neuroblast proliferation central nervous system development cell aging protein localization negative regulation of DNA replication negative regulation of cell proliferation determination of adult lifespan rRNA transcription response to UV response to salt stress embryo development ending in birth or egg hatching response to X-ray response to gamma radiation positive regulation of cardiac muscle cell apoptotic process programmed cell death viral process cerebellum development negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator negative regulation of transforming growth factor beta receptor signaling pathway chromosome breakage positive regulation of histone deacetylation chromatin assembly mitotic G1 DNA damage checkpoint positive regulation of protein oligomerization T cell differentiation in thymus regulation of tissue remodeling cellular protein localization cellular response to UV multicellular organism growth positive regulation of mitochondrial membrane permeability regulation of cell proliferation cellular response to glucose starvation response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process entrainment of circadian clock by photoperiod mitochondrial DNA repair regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast proliferation rhythmic process circadian behavior embryonic organ development negative regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of catalytic activity protein tetramerization chromosome organization neuron apoptotic process regulation of intracellular pH regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter in response to hypoxia intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of thymocyte apoptotic process positive regulation of thymocyte apoptotic process necroptotic process positive regulation of cell cycle arrest cellular response to ionizing radiation cellular response to UV-C mitotic cell cycle arrest intrinsic apoptotic signaling pathway by p53 class mediator regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter positive regulation of release of cytochrome c from mitochondria positive regulation of cell aging replicative senescence oxidative stress-induced premature senescence oligodendrocyte apoptotic process positive regulation of execution phase of apoptosis negative regulation of macromitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of hydrogen peroxide-induced cell death negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of fibroblast apoptotic process negative regulation of DNA biosynthetic process negative regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of cellular senescence positive regulation of intrinsic apoptotic signaling pathway Ras protein signal transduction aging response to inorganic substance response to metal ion response to UV-B response to organonitrogen compound response to organic cyclic compound response to caffeine response to retinoic acid response to vitamin B3 response to cytokine cellular response to heat cellular response to drug wound healing response to amino acid response to antibiotic response to hyperoxia cellular response to organonitrogen compound cellular response to hypoxia base-excision repair cell proliferation positive regulation of gene expression protein sumoylation cell differentiation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus regulation of mitochondrial membrane permeability negative regulation of helicase activity negative regulation of telomerase activity intrinsic apoptotic signaling pathway positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator regulation of cell cycle G2/M phase transition