Search Thermo Fisher Scientific
Mouse VEGFR3 quantitates mouse VEGFR3 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse VEGFR3.
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : AI323512, Chy, Flt-4, Flt4, VEGFR-3, VEGFR3
基因ID : (Mouse) 14257
基因符号 : Flt4
蛋白别名 : chylous ascites, FLT-4, Fms-like tyrosine kinase 4, receptor protein tyrosine kinase, sVEGFR 3, VEGF R3, soluble VEGFR 3, Tyrosine-protein kinase receptor FLT4, Vascular endothelial growth factor receptor 3, vascular endothelial growth factor receptor-3, VEGFR-3
UniProt ID (Mouse) P35917