Clinical Research & Toxicology Peer-Reviewed Literature Library

Mass spectrometry-based discoveries in clinical and translational research

Thermo Fisher Scientific customers all over the world are using our instruments and other products to make critical progress in clinical application areas such as endocrinology, therapeutic drug monitoring, clinical biomarkers, translational research and forensics and toxicology. Click on the topics below to see related scientific publications in peer-reviewed journals.

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TitleAnalyteTechnique

Quantitative

 Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry.synthetic cathinones, metabolitesHRAM MS
 Buprenorphine detection in urine using liquid chromatography-high-resolution mass spectrometry: comparison with cloned enzyme donor immunoassay (ThermoFisher) and homogeneous enzyme immunoassay (immunalysis).buprenorphineHRAM MS
 Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.cytochrome P450HRAM MS
 Analysis of drugs of abuse by online SPE-LC high resolution mass spectrometry: communal assessment of consumption.drugs of abuseHRAM MS
 The use of turbulent flow chromatography for rapid, on-line analysis of tryptic digests.tryptic drugsHRAM MS
 Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking.heterocyclic amines 2-amino-9H-pyrido[2,3-b]indole, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, e-cigaretteTriple Quadrupole MS
 Rapid determination of nine barbiturates in human whole blood by liquid chromatography-tandem mass spectrometry.barbituratesTriple Quadrupole MS
 Liquid chromatography-high resolution-tandem mass spectrometry using Orbitrap technology for comprehensive screening to detect drugs and their metabolites in blood plasma.drugs, drug metabolitesHRAM MS
 Use of LC-HRMS in full scan-XIC mode for multi-analyte urine drug testing - a step towards a 'black-box' solution?psychoactive substances, NPSHRAM MS
 High-Throughput Screening and Quantitation of Target Compounds in Biofluids by Coated BladeSpray-Mass Spectrometry.anabolics, stimulants, diuretics, narcoticsTriple Quadrupole MS
 A liquid chromatography and tandem mass spectrometry method to determine 28 non-volatiledrugs of abuse in exhaled breath.drugs, volatile drugsTriple Quadrupole MS
 Dilute-and-shoot coupled to nanoflow liquid chromatography high resolution mass spectrometry for the determination of drugs of abuse and sport drugs in human urine.DOA, drugs of abuseHRAM MS
 Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice.e-cigaretteTriple Quadrupole MS
 Quantitative analysis of dextran in rat plasma using Q-Orbitrap mass spectrometry based on all ion fragmentation strategy.dextranHRAM MS
 A UHPLC-MS/MS method for the quantification of Δ9-tetrahydrocannabinol and cannabidiol in decoctions and in plasma samples for therapeutic monitoring of medical cannabis.THC, tetrahydrocannabinolTriple Quadrupole MS
 Adsorption of tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl)-1-butanone from aqueous solution with graphene aerogelnitrosamine; tobacco-specificTriple Quadrupole MS
 Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry.oxytocin, fatty acyl, lipidsHRAM MS
 A liquid chromatography-tandem mass spectrometry platform for the routine therapeutic drug monitoring of 14 antibiotics: Application to critically ill pediatric patientsantibioticsTriple quadrupole MS
 Driving Under the Influence of Drugs: A Single Parallel Monitoring-Based Quantification Approach on Whole Blood22 DOAHRAM MS
 Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolamflubromazolam, designer benzodiazepineHRAM MS
 Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapyketamine, midazolame, dehydronorketamine, norgetamine, metabolitesHRAM MS

Screening

 Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular drug screeningHRAM MS 
 Fully automated semi-quantitative toxicological screening in three biological matrices using turbulent flow chromatography/high resolution mass spectrometry.drugs of abuseHRAM MS
 First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.PV8, pyrrolidinophenone, drugs, novel psychoactive substances, NPSHRAM MS
 LC-HR-MS/MS standard urine screening approach: Pros and cons of automated on-line extraction by turbulent flow chromatography versus dilute-and-shoot and comparison with established urine precipitation.drugs, metabolitesHRAM MS
 Comprehensive analysis by liquid chromatography Q-Orbitrap mass spectrometry: Fast screening of peptides and organic molecules.peptides, organic compounds, DOAHRAM MS
 Development of a sensitive untargeted liquid chromatography-high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances.psychoactive substances, NPSHRAM MS
 Automated analysis of dried urine spot (DUS) samples for toxicology screening.DOA, drugs of abuseTriple quadrupole MS
 Characterization and tentative identification of new flunitrazepam metabolites in authentic human urine specimens using liquid chromatography-Q exactive-HF hybrid quadrupole-Orbitrap-mass spectrometry (LC-QE-HF-MS)flunitrazepam HRAM MS
 Detecting drugs in dry bone: a pilot study of skeletal remains with a post-mortem interval over 23 yearsdrugsHRAM GC-MS, HRAM MS
 Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samplesfentanyl analogsTriple quadrupole MS
 Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substancesDOA, drugs of abuseHRAM MS
 Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometryflubromazolam, designer benzodiazepineHRAM MS
 LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples.cathinone analogues, microsamplingHRAM MS
 Liquid chromatography-high resolution mass spectrometry for broad-spectrum drug screening of dried blood spot as microsampling proceduredrugs of abuse, dried blood spotHRAM MS

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TitleAnalyteTechnique
 Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): a novel glycan-relative quantification strategy.INLIGHT, isotope glycan hydrazide tagsHRAM MS
 Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometer.SILAC, mTRAQ, phosphoproteoomicsHRAM MS
 Overcoming challenges and opening new opportunities in glycoproteomics.glycoproteomicsHRAM MS
 Collagen peptides in urine: a new promising biomarker for the detection of colorectal liver metastases.peptidesHRAM MS
 A direct-infusion- and HPLC-ESI-Orbitrap-MS approach for the characterization of intact PEGylated proteins.PEGylated proteinHRAM MS
 Stable, reproducible, and automated capillary zone electrophoresis-tandem mass spectrometry system with an electrokinetically pumped sheath-flow nanospray interface.proteinsHRAM MS
 Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis.proteomeHRAM MS
 Deep proteomic profiling of human carotid atherosclerotic plaques using multidimensional LC-MS/MS.proteomeHRAM MS
 Glycoform analysis of recombinant and human immunodeficiency virus envelope protein gp120 via higher energy collisional dissociation and spectral-aligning strategy.glycoform, protein gp120HRAM MS
 Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer.proteomeHRAM MS
 Using In-Solution Digestion, Peptide Fractionation, and a HRAM MS Mass Spectrometer to Analyze the Proteome of Clathrin-Coated Vesiclesproteome of clathrin-coated vesiclesHRAM MS
 Urine sample preparation in 96-well filter plates to characterize inflammatory and infectious diseases of the urinary tract.proteinsHRAM MS
 Comparative reevaluation of FASP and enhanced FASP methods by LC-MS/MS.proteinsHRAM MS
 A Double-Barrel Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) System to Quantify 96 Interactomes per Day.proteomeHRAM MS
 Quantification of cytokines secreted by primary human cells using multiple reaction monitoring: evaluation of analytical parameters.cytokinesHRAM MS
 A novel and sensitive assay for heme oxygenase activityproteinTriple Quadrupole MS
 Solid-phase extraction of small biologically active peptides on cartridges and microelution 96-well plates from human urinepeptidesTriple Quadrupole MS
 Quantitative Site-Specific Phosphoproteomics of Trichoderma reesei Signaling Pathways upon Induction of Hydrolytic Enzyme Production.phosphoproteomicsHRAM MS
 Implementation of Ultraviolet Photodissociation on a Benchtop HRAM MS Mass Spectrometer and Its Application to Phosphoproteomics.phosphoproteomicsHRAM MS
 Selecting Optimal Peptides for Targeted Proteomic Experiments in Human Plasma Using In Vitro Synthesized Proteins as Analytical Standards.peptidesTriple Quadrupole MS
 Constructing Proteome Reference Map of the Porcine Jejunal Cell Line (IPEC-J2) by Label-Free Mass Spectrometry.proteomeHRAM MS
 Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays.peptidesTriple Quadrupole MS
 Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays.peptidase, human kallikrein-related peptidaseHRAM MS, Triple Quadrupole MS
 Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion.streptococci capturesHRAM MS, Triple Quadrupole MS
 Quantitative Mass Spectrometry To Study Inflammatory Cartilage Degradation and Resulting Interactions with the Complement System.proteinsTriple Quadrupole MS
 Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis.elF4GTriple Quadrupole MS
 Longitudinal investigation of salivary proteomic profiles in the development of early childhood caries.peptidesHRAM MS
 Exploring ECD on a Benchtop HRAM MS Orbitrap Mass Spectrometer.bottom-up proteomics, ECD utilityHRAM MS
 Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.proteins, brainTriple Quadrupole MS
 Ultra-High-Resolution Mass Spectrometry for Identification of Closely Related Dermatophytes with Different Clinical Predilections.proteins, top-down, fungiHRAM MS
 Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications.proteins, brainTriple Quadrupole MS
 Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry.proteomeTriple Quadrupole MS
 Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry.proteomeTriple Quadrupole MS
 Acute Proteomic Changes in the Lung after WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure.proteomeHRAM MS
 iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy.biomarkers, proteinsHRAM MS
 DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discoveryproteins, peptidesHRAM MS
 High-throughput, in-depth and estimated absolution quantification of plasma proteome using data-independent acquisition/ mass spectrometry ("HIAP-DIA")proteinHRAM MS
 Integrating Serum Protein Electrophoresis with Mass Spectrometry, A New Workflow for M-Protein Detection and QuantificationM-proteinHRAM MS
 Large-scale targeted metabolomics method for metabolite profiling of human samplesmetabolitesHRAM MS
 Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and TransporterspeptidesHRAM MS
 Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studiespeptidesHRAM MS
 Vedolizumab quantitation using high-resolution accurate mass-mass spectrometry middle-up protein subunit: method validationvedolizumabHRAM MS

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TitleAnalyteTechnique
 Matrix-assisted laser desorption/ionization for simultaneous quantitation of (acyl-)carnitines and organic acids in dried blood spots.acylcarnitines, carnitines, organic acidsHRAM MS
 An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM).insulin, insuline analogsHRAM MS
 Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry.anionic metabolitesHRAM MS
 Large-scale label-free comparative proteomics analysis of polo-like kinase 1 inhibition via the small-molecule inhibitor BI 6727 (Volasertib) in BRAF(V600E) mutant melanoma cells.polo-like kinase 1, BI6727, Volasertib, BRAF, V600EHRAM MS
 A strategy for sensitive, large scale quantitative metabolomics.metabolomicsHRAM MS
 Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3.NOX4, ITGA3HRAM MS
 Simultaneous quantification of Sphingolipids in small quantities of liver by LC-MS/MSsphingolipidsTriple Quadrupole MS
 Underivatized oxysterols and nanoLC-ESI-MS: A mismatch.oxysterolsHRAM MS, Triple Quadrupole MS
 Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry.25-hydroxy vitamin DHRAM MS
 Detection and quantification of proteins in clinical samples using high resolution mass spectrometry.protein, biomarkerHRAM MS
 High speed capillary zone electrophoresis-mass spectrometry via an electrokinetically pumped sheath flow interface for rapid analysis of amino acids and a protein digest.amino acid, proteinsHRAM MS
 Targeted Metabolomic Analysis of Head and Neck Cancer Cells Using High Performance Ion Chromatography Coupled with a HRAM MS HF Mass Spectrometer.targeted metabolomicsHRAM MS
 MS2PIP prediction server: compute and visualize MS2 peak intensity predictions for CID and HCD fragmentation.prediction models for fragmentationHRAM MS
 Analysis of Cell Metabolism Using LC-MS and Isotope Tracers.metabolismHRAM MS
 Measurement of Lung Phosphatidylcholines in Exhaled Breath Particles by a Convenient Collection Procedure.phosphatidylcholinesTriple Quadrupole MS
 Metabolism of human insulin after subcutaneous administration: A possible means to uncover insulin misuse.insulin, insulin metabolitesHRAM MS
 Histamine quantification in human plasma using high resolution accurate mass LC-MS technology.histamineHRAM MS
 Sensitive, Simple, and Robust Nano-Liquid Chromatography-Mass Spectrometry Method for Amyloid Protein Subtyping.amyloid proteinHRAM MS
 Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.oxysterolsHRAM MS
 In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant.α-pyrrolidinopentiothiophenoneHRAM MS
 Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in AlzheimerDisease and Frontotemporal Lobar Degeneration.visinin-like proteinTriple Quadrupole MS
 Development and Evaluation of a Parallel Reaction Monitoring Strategy for Large-Scale Targeted Metabolomics Quantification.metabolitesHRAM MS
 Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.PEGylated proteinHRAM MS
 Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells.protein, estrogen receptorHRAM MS, Triple Quadrupole MS
 Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery.thromboxaneTriple Quadrupole MS
 Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.APOE, apolipoproteinTriple Quadrupole MS
 Associations between calcium-phosphate metabolism and coronary artery calcification; a cross sectional study of a middle-aged general population.parathyroid hormone (PTH) and 25-hydroxyvitamin DTriple Quadrupole MS
 Transfer of developmental neurotoxin β-N-methylamino-l-alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis.BMAA, neurotoxinTriple Quadrupole MS
 Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoringangiotensin II-regulated proteinsTriple Quadrupole MS
 Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.carboxyl ester lipase (CEL)Triple Quadrupole MS
 An analytical strategy to investigate Semen Strychni nephrotoxicity based on simultaneous HILIC-ESI-MS/MS detection of Semen Strychni alkaloids, tyrosine and tyramine in HEK 293t cell lysates.semen strychini alkaloids, tyrosine, tyramineHRAM MS
 Simultaneous Determination of Multiple Intracellular Primary Metabolites by Ultrahigh Performance Liquid Chromatography Coupled with a HRAM MS HF Mass Spectrometer.primary metabolitesHRAM MS
 Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis.biomarkers, polar metabolites, lipidsHRAM MS
 Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus.plasmalogenTriple Quadrupole MS
 25C‐NBOMe and 25I‐NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high‐resolution mass spectrometry25C-NBOMe, 25I-NBOMeHRAM MS
 Determination of amino acids in colon cancer cells by using UHPLC-MS/MS and [U-13C5]-glutamine as the isotope tracer.amino acidsTriple Quadrupole MS
 Identification and Characterization of Cardiac Troponin T Fragments in Serum of Patients Suffering from Acute Myocardial Infarction.biomarker, cardiac troponin THRAM MS
 Identification and quantitation of phosphatidylethanols in oral fluid by liquid chromatography-tandem mass spectrometry.phospatidylethanolTriple Quadrupole MS
 A Nontargeted UHPLC-HRMS Metabolomics Pipeline for Metabolite Identification: Application to Cardiac Remote Ischemic Preconditioning.biomarkersHRAM MS
 Expanding the knowledge on dried blood spots and LC-MS-based protein analysis: two different sampling materials and six protein targets.proteinHRAM MS, Triple Quadrupole MS
 Absolute Quantification of Aβ1-42 in CSF Using a Mass Spectrometric Reference Measurement Procedure.protein, biomarkerHRAM MS
 Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.fructose 1,6-biphosphate, aldose mediate glucoseTriple Quadrupole MS
 Quantification of xanthine- and uric acid-related compounds in urine using a "dilute-and-shoot" technique coupling ultra-high-performance liquid chromatography and high-resolution Orbitrap mass spectrometry.xanthine, uric acidHRAM MS
 Holistic Lipidomics of the Human Gut Phenotype Using Validated Ultra-High-Performance Liquid Chromatography Coupled to Hybrid Orbitrap Mass Spectrometry.fatty acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, sterolsHRAM MS
 Lower plasma choline levels are associated with sleepiness symptoms.cholineTriple Quadrupole MS
 Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaMSites to Activation.AMPKTriple Quadrupole MS
 Easy, Fast, and Reproducible Quantification of Cholesterol and Other Lipids in Human Plasma by Combined High Resolution MSX and FTMS Analysis.cholesterol, glycerolipids, sphingolipids, sterol estersHRAM MS
 Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells.peptidesTriple Quadrupole MS
 Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing.amino acid, lipidTriple Quadrupole MS
 Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry.dinnutuximabTriple Quadrupole MS
 N6-(2-Deoxy-d- erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5- N-(2-hydroxy-3-buten-1-yl)-formamidopyrimidine Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells.nucleobase adductsTriple Quadrupole MS
 Rapid detection and quantification of aminoglycoside phosphorylation products using direct‐infusion high‐resolution and ultra‐high‐performance liquid chromatography/mass spectrometryaminoglycoside phosporylation productsHRAM MS
 Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression.pentraxin receptorTriple Quadrupole MS
 Total Fatty Acid Analysis of Human Blood Samples in One Minute by High-Resolution Mass Spectrometry.fatty acidsHRAM MS
 Bioactive Lipids in Sputum of Older Adults with Asthma as Potential Markers of Disease PhenotypeslipidsTriple Quadrupole MS
 How do cancer-sniffing dogs sort biological samples? Exploring case-control samples with non-targeted LC-Orbitrap, GC-MS, and immunochemistry methods.biomarkers, polar metabolites, lipidsHRAM MS
 A validated multi-matrix platform for metabolomic fingerprinting of human urine, feces and plasma using ultra-high performance liquid-chromatography coupled to hybrid orbitrap high-resolution mass spectrometry.biomarkersHRAM MS
 Rapid analysis of pyridinoline and deoxypyridinoline in biological samples by liquid chromatography-mass spectrometry and silica hydride column.pyridinoline, deoxypyridinolineHRAM MS
 Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer.lipidsHRAM MS
 Plasma free metanephrines for diagnosis of neuroblastoma patients.metanephrines, plasma free metanephrinesTriple Quadrupole MS
 Strain-Level Differentiation of Bacteria by Paper Spray Ionization Mass Spectrometry.bacteriaHRAM MS
 Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome.untargeted, amino acids, sphingolipids, fatty acidsHRAM MS, Triple Quadrupole MS
 An Integrated Approach to Characterize Intestinal Metabolites of Four Phenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant Activity Evaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay.biomarkersHRAM MS
 Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis.biomarkersHRAM MS
 Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile.proteomes, lipidsHRAM MS
 Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass SpectrometryamatoxinsHRAM MS
 Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry.copper, ceruloplasminICP-MS
 Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae speciespollen allergenHRAM MS
 Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population.iodineICP-MS
 Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicineimmunosuppressantsClinical Analyzer
 High-precision isotopic analysis of serum and whole blood Cu, Fe and Zn to assess possible homeostasis alterations due to bariatric surgery.copper, iron, zincICP-MS
 LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patientsspingolipidsHRAM MS
 Metabolism Study of N-Methyl 2-amino Indane (NM2AI) and Determination of Metabolites in Biological Samples by LC-HRMSN-methyl-2-aminoindaneHRAM MS
 Purity determination of synthetic glucagon using a mass balance approachglucagonHRAM MS
 Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection.pepsinogen, element tagged immunoassayICP-MS

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TitleAnalyteTechnique
 A multipronged deep omics-based investigation of COVID-19 plasma samples identifies key molecular networks of disease severity progressionCOVID-19HRAM MS
 Global N‐glycan site occupancy of HIV‐1 gp120 by metabolic engineering and high‐resolution intact mass spectrometry.HIVHRAM MS
 A novel function of IMPA2, plays a tumor-promoting role in cervical cancercancerHRAM MS
 A preliminary study procedure for detection of polyamines in plasma samples as a potential diagnostic tool in prostate cancerpolyaminesHRAM MS
 A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunityCOVID-19HRAM MS
 Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responsesCOVID-19HRAM MS
 Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage. COVID-19HRAM MS
 Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus SyndromeZikaHRAM MS
 Cerebrospinal Fluid of Preeclamptic and Normotensive Pregnant Women Compared to Nonpregnant Women Analyzed with Mass SpectrometryproteinHRAM MS
 Detection of Head and Neck Cancer Based on Longitudinal Changes in Serum Protein Abundance AcancerHRAM MS
 Development and fit-for-purpose verification of an LC-MS method for quantitation of hemagglutinin and neuraminidase proteins in influenza virus-like particle vaccine candidatesinfluenzaHRAM MS
 Development of mass spectrometry-based targeted assay for direct detection of novel SARS-CoV-2 coronavirus from clinical specimensCOVID-19HRAM MS
 Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesisdisease pathogenesisHRAM MS
 Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohortsCOVID-19HRAM MS
 Evidence of Structural protein damage and membrane lipid remodeling in Red Blood Cells from COVID-19 patients COVID-19HRAM MS
 Exosomes in plasma for protein based cancer biomarkers: A clinical research tool using UHPLC-MSexosomesHRAM MS
 High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humanstuberculosisHRAM MS
 Identication of novel salivary candidate protein biomarkers for tuberculosis diagnosistuberculosisHRAM MS
 Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomicsCOVID-19HRAM MS
 Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in childrentuberculosisHRAM MS
 Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected casesexosomes, plasma, amnionic fluidHRAM MS
 LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapycardiac diseaseHRAM MS
 Mass spectrometry-based absolute quantification of amyloid proteins in pathology tissue specimens: Merits and limitationsamyloid proteinHRAM MS, triple quadrupole MS
 Mechanism of succinate efflux upon reperfusion of the ischaemic heart cardiac diseaseHRAM MS
 Nanomedicine therapies modulating Macrophage Dysfunction: a potential strategy to attenuate Cytokine Storms in severe infectionsnanomedicineHRAM MS
 Proteomics as a tool for live attenuated influenza vaccine characterisationinfluenzaHRAM MS
 Proteomics of Select Neglected Tropical DiseasesDengueHRAM MS
 Proteotyping SARS-CoV‑2 Virus from Nasopharyngeal Swabs: A Proof-of-Concept Focused on a 3 Min Mass Spectrometry WindowCOVID-19HRAM MS
 Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial FibrillationproteinHRAM MS
 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. COVID-19HRAM MS
 Rapid quantification of insulin degludec by immunopurification combined with liquid chromatography high-resolution mass spectrometryinsulin degludecHRAM MS
 Role of Multiomics Data to Understand Host–Pathogen Interactions in COVID-19 PathogenesisCOVID-19HRAM MS
 Shortlisting SARS-CoV-2 Peptides for Targeted Studies from Experimental Data-Dependent Acquisition Tandem Mass Spectrometry DataCOVID-19HRAM MS
 Simultaneous quantification of major capsid protein of human papillomavirus 16 and human papillomavirus 18 in multivalent human papillomavirus vaccines by liquid chromatography-tandem mass spectrometryHPVHRAM MS
 Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS analysisCOVID-19HRAM MS
 Update on Proteomic approaches to uncovering virus-induced protein alterations and virus –host protein interactions during the progression of viral infectionH1N1HRAM MS
 Zika Infection Disrupts Proteins Involved in the Neurosensory SystemZikaHRAM MS

No records were found matching your criteria

No records were found matching your criteria

TitleAnalyteTechnique
 Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS assay.teicoplaninHRAM MS
 The development and validation of a method using high-resolution mass spectrometry (HRMS) for the qualitative detection of antiretroviral agents in human blood.antiretroviral drugs, HIV drugsHRAM MS
 Assessment of tandem mass spectrometry and high-resolution mass spectrometry for the analysis of bupivacaine in plasma.bupivacaineTriple Quadrupole MS, HRAM MS
 A high-resolution accurate mass (HR/AM) approach to identification, profiling and characterization of in vitro nefazodone metabolites using a hybrid quadrupole Orbitrap (Q-Exactive).nefazodone metabolitesHRAM MS
 Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry.acetomenophen, alicylic acidHRAM MS
 Quantification of active infliximab in human serum with liquid chromatography–tandem mass spectrometry using a tumor necrosis factor alpha -based pre-analytical sample purification and a stable isotopic labeled infliximab bio-similar as internal standard:infliximabTriple Quadrupole MS
 Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.phenobarbital, phenytoin, carbamazepineHRAM MS
 Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation.drugs, antihypertensiveHRAM MS
 Development and validation of an LC-MS/MS assay for the quantification of efavirenz in different biological matrices.efavirenzTriple Quadrupole MS
 Development of a Simple and Rapid Method to Measure the Free Fraction of Tacrolimus in Plasma Using Ultrafiltration and LC-MS/MS.tacrolimus, immunosuppressantTriple Quadrupole MS
 Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment.trastuzumabTriple Quadrupole MS
 Dried blood spot validation of five immunosuppressants, without hematocrit correction, on two LC-MS/MS systems.tacrolimus, sirolumus, everolimus, cyclosporin A, mycophenolic acidTriple Quadrupole MS
 Ultra-fast quantitation of voriconazole in human plasma by coated blade spray mass spectrometry.voriconazoleTriple Quadrupole MS
 LC-MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs.Fab-bound colchicine, Fab fragmentsTriple Quadrupole MS
 Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry.voriconazoleTriple Quadrupole MS
 Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Qexactive high-resolution benchtop quadrupole orbitrap mass spectrometer.larotaxelHRAM MS
 Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry.benzodiazepines flubromazolam, pyrazolamHRAM MS
 Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS).ISD, immunosuppressive drugsTriple Quadrupole MS
 Development and validation of a liquid chromatography/tandem mass spectrometry method for determination of caspofungin in dried blood spots.capsofunginTriple Quadrupole MS
 Development and validation of a targeted affinity-enrichment and LC-MS/MS proteomics approach for the therapeutic monitoring of adalimumab.adalimumabHRAM MS
 An LC-MS/MS method for quantification of daptomycin in dried blood spot: Application to a pharmacokinetics study in critically ill patientsdaptomycinTriple Quadrupole MS
 Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometryantifungalsPaperSpray Triple quadrupole MS

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TitleAnalyteTechnique

Gas chromatography

 Development of a HS-SPME/GC–MS method for the analysis of volatile organic compounds from fabrics for forensic reconstruction applicationsVOCs for forensic useHRAM GC-MS
 Non-targeted acquisition strategy for screening doping compounds based on GC-EI-hybrid quadrupole-Orbitrap mass spectrometry: focus on exogenous anabolic steroidsanabolic steroidsHRAM GC-MS
 Development of a high-throughput screening analysis for 288 drugs and poisons in human blood using Orbitrap technology with gas chromatography-high resolution accurate mass spectrometry.drugs, poisonsHRAM GC-MS
 Using gas chromatography and mass spectrometry to determine 25-hydroxyvitamin D levels for clinical assessment of vitamin D deficiency.25-hydroxyvitamin DGC-MS/MS

Multiplexing

 UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasmaantiretroviral drugsLC-MS/MS
 UPLC–MS/MS method for the simultaneous quantification of bictegravir and 13 others antiretroviral drugs plus cobicistat and ritonavir boosters in human plasma immunosuppressantLC-MS/MS
 An automated, high-throughput method for targeted quantification of intact insulin and its therapeutic analogs in human serum or plasma coupling mass spectrometric immunoassay with high resolution and accurate mass detection (MSIA-HR/AM).insulin, insulin analogsHRAM MS
 Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays.peptidesTriple Quadrupole MS
 Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays.peptidaseTriple Quadrupole MS
 Targeted Mass Spectrometry-Based Assays for Relative Quantification of 30 Brain-Related Proteins and Their Clinical Applications.proteinsTriple Quadrupole MS

Paper spray

 Paper spray ionization mass spectrometry: recent advances and clinical applications.reviewHRAM MS and Triple Quadrupole MS
 Rapid analysis of fentanyls and other novel psychoactive substances in substance use disorder patient urine using paper spray mass spectrometry.fentanylsHRAM MS
 Paper Spray Ionization Coupled to High Resolution Tandem Mass Spectrometry for Comprehensive Urine Drug Testing in Comparison to Liquid Chromatography-Coupled Techniques after Urine Precipitation or Dried Urine Spot Workup.drugs of abuseHRAM MS

ICP-MS

 Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detectionHER2ICP-MS
 A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MStrace elementsICP-MS
 Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid.iodineICP-MS
 Simultaneous determination of gastric cancer biomarkers pepsinogen PGI/PGII using element tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection.pepsinogen, element tagged immunoassayICP-MS
 Biomedical copper speciation in relation to Wilson's disease using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry.copper, sulfur, phosphorus, ironICP-MS
 Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population.iodineICP-MS
 High-precision isotopic analysis of serum and whole blood Cu, Fe and Zn to assess possible homeostasis alterations due to bariatric surgery.copperICP-MS
 Blood and plasma titanium levels associated with well-functioning hip implants.titaniumICP-MS
 Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection.HER2ICP-MS
 Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases.trace elementsICP-MS
 Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology.cadmium, seleniumICP-MS
 Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing.iodineICP-MS
 Whole blood selenium determination by inductively coupled plasma mass spectrometry.seleniumICP-MS
 Quantification of multiple elements in dried blood spot samples.trace elementsICP-MS
 Urinary chromium is associated with changes in leukocyte miRNA expression in obese subjects.chromiumICP-MS
 Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.trace elementsICP-MS
 Determination of Thirteen Trace and Toxic Elements in Urine Using Inductively Coupled Mass Spectrometry.trace elementsICP-MS
 Evaluation of an Element-Tagged Duplex Immunoassay Coupled with Inductively Coupled Plasma Mass Spectrometry Detection: A Further Study for the Application of the New Assay in Clinical LaboratoryCEA, AFP, α-fetoproteinICP-MS
 Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid.iodineICP-MS

Ion chromatography

 Purity determination of synthetic glucagon using a mass balance approachglucagon and impurtieiesHRAM IC-MS
 Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry.anionic metabolitesHRAM IC-MS
 An improved reference method for serum cations measurement by ion chromatography.cationsIC
 Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic Acids.organic acidsIC-MS/MS

Dried Matrix Spots

 A novel LC-MS/MS assay for vitamin B 1, B 2 and B 6 determination in dried blood spots and its application in childrenvitamin B1, B2, B6, dried blood spotHRAM MS
 Analysis of cyclosporin A in dried blood spots using liquid chromatography tandem mass spectrometrycyclosporin A, dried blood spotHRAM MS
 Automated Analysis of Dried Urine Spot (DUS) Samples for Toxicology Screeningdrugs of abuse, dried urine spotHRAM MS
 State of Science in Dried Blood Spotsdried blood spotsHRAM MS
 Feasibility of Patient-Centric Remote Dried Blood Sampling: The Prediction, Risk, and Evaluation of Major Adverse Cardiac Events (PRE-MACE) Studycardiac disease, dried blood spotHRAM MS
 Power of Orbitrap‐based LC‐high resolution‐MS/MS for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on‐spot cleavage in comparison to established LC–MSn or GC–MS proceduresdrugs of abuse, dried urine spotHRAM MS