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产品信息
PEP-175
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-175 is a 15 amino acid synthetic peptide whose sequence is from human proteasome 20S Z. The sequence of this peptide is (amino to carboxy terminus): C-E (263)-I-E-V-L-E-E-T-V-Q-T-M-D-T-S (NH2) (277)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S Z, catalog # PA1-979. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
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生物信息学
蛋白别名: Macropain chain Z; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type, 7; proteasome catalytic subunit 2; proteasome subunit alpha; Proteasome subunit beta type-7; Proteasome subunit Z; protein serine kinase c17; RP11-101K10.7
基因别名: PSMB7; Z
UniProt ID: (Human) Q99436
Entrez Gene ID: (Human) 5695
