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产品信息
PEP-1167
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 18 amino acids near the amino terminus of human APBA2.
PEP-1167 can be used as a blocking peptide with polyclonal antibody PA5-21053.
靶标信息
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid-beta A4 precursor protein-binding family A member 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-like protein
基因别名: APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; X11-BETA; X11L
UniProt ID: (Human) Q99767
Entrez Gene ID: (Human) 321
