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产品信息
PEP-1241
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 19 amino acids near the amino terminus of human ATP2C2.
PEP-1241 can be used as a blocking peptide with polyclonal antibody PA5-21127.
靶标信息
ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
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生物信息学
蛋白别名: ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2; Ca(2+)/Mn(2+)-ATPase 2C2; Calcium-transporting ATPase type 2C member 2; secretory pathway Ca(2+)-ATPase 2; Secretory pathway Ca(2+)-transporting ATPase type 2; secretory pathway calcium ATPase 2; SPCA2
基因别名: ATP2C2; KIAA0703; SPCA2
UniProt ID: (Human) O75185
Entrez Gene ID: (Human) 9914
