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产品信息
PEP-1406
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 14 amino acid peptide near the carboxy terminus of human CARMA2.
PEP-1406 can be used as a blocking peptide with polyclonal antibody PA5-34363.
靶标信息
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bcl10-interacting maguk protein 2; CARD-containing MAGUK protein 2; Carma 2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14
基因别名: BIMP2; CARD14; CARMA2; PRP; PSORS2; PSS1
UniProt ID: (Human) Q9BXL6
Entrez Gene ID: (Human) 79092
