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产品信息
450-05-25UG
产品规格
种属
Human
已发表种属
Mouse
Expression System
E. coli
氨基酸序列
MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
分子量
18.5 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
Recombinant Human CDNF is an 18.5 kDa protein consisting of 162 amino acids, including 8 cysteine residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: arginine-rich, mutated in early stage tumors-like 1; ARMET-like protein 1; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
基因别名: ARMETL1; CDNF
UniProt ID: (Human) Q49AH0
Entrez Gene ID: (Human) 441549
