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Highest antigen sequence indentity to the following orthologs: Mouse (58%), Rat (58%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51870. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: choroideremia (Rab escort protein 1); Choroideremia protein; Rab escort protein 1; Rab proteins geranylgeranyltransferase component A 1; REP-1; TCD protein
基因别名: CHM; DXS540; GGTA; HSD-32; REP-1; REP1; TCD
UniProt ID: (Human) P24386
Entrez Gene ID: (Human) 1121