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Highest antigen sequence indentity to the following orthologs: Mouse (98%), Rat (98%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53124. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 1; cholinergic receptor; cholinergic receptor, muscarinic 1; M1 mAChR; MGC30125; Muscarinic acetylcholine receptor M1
基因别名: CHRM1; HM1; M1; M1R
UniProt ID: (Human) P11229
Entrez Gene ID: (Human) 1128