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Highest antigen sequence indentity to the following orthologs: Mouse (53%), Rat (53%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84691. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
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蛋白别名: Collagen 4; Collagen alpha-6(IV) chain; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-6; collagen, type IV, alpha 6; dJ889N15.4 (Collagen Alpha 6(IV))
基因别名: COL4A6; CXDELq22.3; DELXq22.3; DFNX6
UniProt ID: (Human) Q14031
Entrez Gene ID: (Human) 1288