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Highest antigen sequence indentity to the following orthologs: Mouse (73%), Rat (73%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83847. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
COMMD5 is a protein coding gene. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: COMM domain-containing protein 5; FLJ13008; HCaRG; Hypertension-related calcium-regulated gene protein
基因别名: COMMD5; HCARG; HT002
UniProt ID: (Human) Q9GZQ3
Entrez Gene ID: (Human) 28991