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产品信息
PEP-1453
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 15 amino acid peptide near the carboxy terminus of human CRIM2.
PEP-1453 can be used as a blocking peptide with polyclonal antibody PA5-34411.
靶标信息
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
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生物信息学
蛋白别名: CRIM-2; cysteine rich BMP regulator 2 (chordin-like); Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; kielin; Kielin/chordin-like protein; Kielin/chordin-like protein 1
基因别名: CRIM2; KCP; KCP1; NET67
UniProt ID: (Human) Q6ZWJ8
Entrez Gene ID: (Human) 375616
