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产品信息
PEP-162
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-162 is a 18 amino acid synthetic peptide corresponding to amino acid residues 1043-1058 from human CRM1. The sequence of this peptide is (amino to carboxy terminus): C R Q A D E E K H K R Q M S V P G S.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-083. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.
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