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产品信息
RP-94902
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
KPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHE
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (33%), Rat (33%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56396. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
As basal cells of stratified squamous epithelia begin to migrate in response to wound healing, they lose their cell-substrate adhesion junctions, the hemidesmosomes. The hemidesmosome is an adhesion structure of the epidermal-dermal junction in keratinocytes. When keratinocytes migrate laterally or upward to differentiate they must control the formation and disintegration of the hemidesmosomes. The bullous pemphigoid antigen BPAG1 is a hemidesmosomal protein of the cutaneous basement membrane zone. The primary sequence deduced from full-length human cDNAs predicts that this molecule consists of a central rod region and flanking globular domains. A neuronal isoform, BPAG1n3 is the result of differential splicing of BPAG1. BPAG1n3 is distinguished by its initial 32 amino acid residues and by the absence of the amino-terminal half of the actin-binding domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; BPA; Bullous pemphigoid antigen 1; Dystonia musculorum protein; Dystonin; Hemidesmosomal plaque protein; trabeculin-beta
基因别名: BP230; BP240; BPA; BPAG1; CATX-15; CATX15; D6S1101; DMH; DST; DT; EBSB2; HSAN6; KIAA0728; MACF2
UniProt ID: (Human) Q03001
Entrez Gene ID: (Human) 667
