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产品信息
RP-108031
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
GVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQ
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (74%), Rat (74%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-111727. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine/threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions. DYRK3 is a negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3; Dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; KSR; protein kinase Dyrk3; REDK; Regulatory erythroid kinase; RP11-343H5.2; RSU2
基因别名: DYRK3; DYRK5; hYAK3-2; RED; REDK
UniProt ID: (Human) O43781
Entrez Gene ID: (Human) 8444
