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产品信息
PEP-1577
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 15 amino acids near the carboxy terminus of human ERRF2.
PEP-1577 can be used as a blocking peptide with polyclonal antibody PA5-34534. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
靶标信息
The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ER-related factor; Estrogen receptor-related factor; RP11-5P18.4; Steroid receptor-associated and regulated protein; Steroid receptor-regulated protein
基因别名: C1orf64; ERRF; SRARP; SSPR
UniProt ID: (Human) Q8NEQ6
Entrez Gene ID: (Human) 149563
