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产品信息
RP-90837
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
ASFKMDPLISWQSGFVTGTFDLQEVLFHGGSSFTVLRCTSFALESCAHPDRHYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQVEPVRREGELWHIRAQ
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (93%), Rat (93%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53748. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
HHATL (Hedgehog Acyltransferase-Like) is a gene that codes for a protein involved in the regulation of Hedgehog signaling pathways. HHATL is located on chromosome 7q36.3. Structurally, the protein encoded by this gene is characterized by an acyltransferase domain, which plays a crucial role in the N-palmitoylation of the Sonic Hedgehog (Shh) protein, a process essential for its proper signaling activity and distribution. Functionally, HHATL has been implicated in various biological processes, including amelioration of endoplasmic reticulum stress through autophagy. The gene is expressed in several tissues, with notable high expression in the heart, suggesting a potential role in cardiac development and function. Dysfunction in HHATL could lead to anomalies in Hedgehog signaling, impacting various developmental and cellular processes.
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生物信息学
蛋白别名: Glycerol uptake/transporter homolog; GUP1 glycerol uptake/transporter homolog; Hedgehog acyltransferase-like protein; membrane bound O-acyltransferase domain containing 3; Protein-cysteine N-palmitoyltransferase HHAT-like protein
基因别名: C3orf3; GUP1; HHATL; KIAA1173; MBOAT3; MSTP002; OACT3
UniProt ID: (Human) Q9HCP6
Entrez Gene ID: (Human) 57467
