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产品信息
PHC4244
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
CHO cells
分子量
23 kDa
分类
Recombinant
类型
Protein
纯度
>95%
内毒素浓度
<1 EU/µg
活性
EC50 ~ 1 U/mL; determined by a cytopathic inhibition assay on human A549 lung carcinoma cells with encephalomyocarditis virus (EMCV).
偶联物
形式
Liquid
纯化类型
purified
保存液
50mM sodium acetate with 0.1% BSA
内含物
no preservative
保存条件
-80°C
运输条件
Dry ice
产品详细信息
Source: cDNA obtained from human fibroblast interferon beta 1a mRNA expressed in CHO cells.
Storage: After receipt, the product may be stored at -20ºC for short-term use (<6 months). For long-term storage, store the product at -70ºC or below for retention of full activity. Thaw product vial by incubation in cold tap water until just thawed. The contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
靶标信息
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
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生物信息学
蛋白别名: beta 1; Fibroblast interferon; IFN-beta; Interferon; Interferon beta; Interferon beta-1a; interferon, beta 1, fibroblast; interferon-beta
基因别名: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
