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产品信息
RP-108137
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
CGLITSKYDGRVPDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQ
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67484. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV beta.3 is an accessory K+ channel protein which regulates the activity of the pore-forming alpha subunit and alters the functional properties of Kv1.5. KV beta.3 localizes to the cytoplasm and is expressed in the brain, with highest expression detected in the cerebellum, and weakest expression seen in the frontal and temporal lobes. No KV beta.3 expression is detected in the heart, spinal cord, lung, liver, kidney, pancreas, placenta or skeletal muscle.
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生物信息学
蛋白别名: K(+) channel subunit beta-3; Kv-beta-3; KV-beta.3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium voltage-gated channel, shaker-related subfamily, beta member 3; Voltage-gated potassium channel subunit beta-3
基因别名: AKR6A9; KCNA3.1B; KCNA3B; KCNAB3; KV-BETA-3
UniProt ID: (Human) O43448
Entrez Gene ID: (Human) 9196
