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产品信息
RP-90841
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
ELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFL
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (41%), Rat (41%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53212. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Exophilin-3; leaden; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
基因别名: MLPH; SLAC2-A; SLAC2A
UniProt ID: (Human) Q9BV36
Entrez Gene ID: (Human) 79083
