Invitrogen

Human PRR5L Synthetic Peptide

产品信息

PEP-1243

应用

建议稀释比

已发表文章

对照试剂 (Ctrl)

Assay-dependent

阻断反应 (BLOCK)

Assay-dependent

产品规格

种属反应

Human

分类

Synthetic

类型

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with 0.1% BSA

内含物

0.02% sodium azide

保存条件

-20°C

产品详细信息

This peptide corresponds to 17 amino acids near the center of human PRR5L.

PEP-1243 can be used as a blocking peptide with polyclonal antibody PA5-21129.

靶标信息

Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.

仅用于科研。不用于诊断过程。未经明确授权不得转售。